Details der Publikation - Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

Abstract An ovine rotavirus (OVR) strain, 762, was isolated from a 30-day-old lamb affected with severe gastroenteritis, in Zaragoza, Spain, and the VP4, VP7, VP6, NSP4, and NSP5/NSP6 genes were subsequently characterized molecularly. Strain OVR762 was classified as a P[14] rotavirus, as the VP4 and VP8* trypsin-cleavage product of the VP4 protein revealed the highest amino acid (aa) identity (94% and 97%, respectively) with that of the P11[14] human rotavirus (HRV) strain PA169, isolated in Italy. Analysis of the VP7 gene product revealed that OVR762 possessed G8 serotype specificity, a type common in ruminants, with the highest degree of aa identity (95–98%) shared with serotype G8 HRV, bovine rotavirus, and guanaco (Lama guanicoe) rotavirus strains. Moreover, strain OVR762 displayed a bovine-like NSP4 (genotype E2) and NSP5/NSP6 (genotype H3), and a VP6 genotype I2, as well as a long electropherotype pattern. This is the first report of a lamb rotavirus with P[14] and G8 specificities, providing additional evidence for the wide genetic and antigenic diversity of group A rotaviruses..

Medienart:	E-Artikel

Erscheinungsjahr:	2008
Erschienen:	2008

Enthalten in:	Zur Gesamtaufnahme - volume:37
Enthalten in:	Virus genes - 37(2008), 2 vom: 26. Juli, Seite 250-265

Sprache:	Englisch

Beteiligte Personen:	Ciarlet, Max [VerfasserIn] Hoffmann, Christian [VerfasserIn] Lorusso, Eleonora [VerfasserIn] Baselga, Rafael [VerfasserIn] Cafiero, Maria Assunta [VerfasserIn] Bányai, Krisztián [VerfasserIn] Matthijnssens, Jelle [VerfasserIn] Parreño, Viviana [VerfasserIn] de Grazia, Simona [VerfasserIn] Buonavoglia, Canio [VerfasserIn] Martella, Vito [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.43$jMedizinische Mikrobiologie
Themen:	Gastroenteritis Genetic diversity Genome Genotype Lamb NSP4 NSP5 Reassortment Rotavirus VP4 VP6 VP7

Anmerkungen:	© Springer Science+Business Media, LLC 2008

doi:	10.1007/s11262-008-0257-6

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2084320550

Internformat


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520			\|a Abstract An ovine rotavirus (OVR) strain, 762, was isolated from a 30-day-old lamb affected with severe gastroenteritis, in Zaragoza, Spain, and the VP4, VP7, VP6, NSP4, and NSP5/NSP6 genes were subsequently characterized molecularly. Strain OVR762 was classified as a P[14] rotavirus, as the VP4 and VP8* trypsin-cleavage product of the VP4 protein revealed the highest amino acid (aa) identity (94% and 97%, respectively) with that of the P11[14] human rotavirus (HRV) strain PA169, isolated in Italy. Analysis of the VP7 gene product revealed that OVR762 possessed G8 serotype specificity, a type common in ruminants, with the highest degree of aa identity (95–98%) shared with serotype G8 HRV, bovine rotavirus, and guanaco (Lama guanicoe) rotavirus strains. Moreover, strain OVR762 displayed a bovine-like NSP4 (genotype E2) and NSP5/NSP6 (genotype H3), and a VP6 genotype I2, as well as a long electropherotype pattern. This is the first report of a lamb rotavirus with P[14] and G8 specificities, providing additional evidence for the wide genetic and antigenic diversity of group A rotaviruses.
650		4	\|a Rotavirus
650		4	\|a Gastroenteritis
650		4	\|a Genome
650		4	\|a Genotype
650		4	\|a Genetic diversity
650		4	\|a Reassortment
650		4	\|a Lamb
650		4	\|a VP4
650		4	\|a VP6
650		4	\|a VP7
650		4	\|a NSP4
650		4	\|a NSP5
700	1		\|a Hoffmann, Christian \|4 aut
700	1		\|a Lorusso, Eleonora \|4 aut
700	1		\|a Baselga, Rafael \|4 aut
700	1		\|a Cafiero, Maria Assunta \|4 aut
700	1		\|a Bányai, Krisztián \|4 aut
700	1		\|a Matthijnssens, Jelle \|4 aut
700	1		\|a Parreño, Viviana \|4 aut
700	1		\|a de Grazia, Simona \|4 aut
700	1		\|a Buonavoglia, Canio \|4 aut
700	1		\|a Martella, Vito \|4 aut
773	0	8	\|i Enthalten in \|t Virus genes \|d Springer US, 1987 \|g 37(2008), 2 vom: 26. Juli, Seite 250-265 \|h Online-Ressource \|w (DE-627)320492052 \|w (DE-600)2011138-1 \|w (DE-576)103868178 \|x 1572-994X \|7 nnns
773	1	8	\|g volume:37 \|g year:2008 \|g number:2 \|g day:26 \|g month:07 \|g pages:250-265
856	4	0	\|u https://dx.doi.org/10.1007/s11262-008-0257-6 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
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912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
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912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
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912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
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Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

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