Details der Publikation - A Long-Term Survivor of Disseminated Aspergillus and Mucorales Infection: An Instructive Case

A Long-Term Survivor of Disseminated Aspergillus and Mucorales Infection: An Instructive Case

Abstract Invasive fungal infections remain major causes of infection-related mortality in hematopoietic stem cell transplantation (HSCT) patients. Mixed infections and multiple organ involvement have been reported in these patients. Here, we report a case of mixed Aspergillus and Mucorales infection involving the lungs, brain, spleen and bone in a HSCT patient with relapsed acute myeloid leukemia, who finally improved with triple antifungal therapy and neurosurgical evacuation of brain abscesses. She was put on lifelong secondary prophylaxis with posaconazole with excellent compliance and no sign of toxicity despite over 10 years of drug administration. Serial galactomannan measurements and positron emission tomography/computed tomography were used and were helpful for disease activity monitoring. This is an instructive case of long-term survival after a severe combined mould infection..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:178
Enthalten in:	Mycopathologia - 178(2014), 5-6 vom: 03. Aug., Seite 465-470

Sprache:	Englisch

Beteiligte Personen:	Davoudi, Setareh [VerfasserIn] Anderlini, Paolo [VerfasserIn] Fuller, Gregory N. [VerfasserIn] Kontoyiannis, Dimitrios P. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.00$jMedizin: Allgemeines
Themen:	AML Hematopoietic stem cell transplant PET/CT Posaconazole Secondary prophylaxis Toxicity

Anmerkungen:	© Springer Science+Business Media Dordrecht 2014

doi:	10.1007/s11046-014-9785-x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2081548720

Internformat


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520			\|a Abstract Invasive fungal infections remain major causes of infection-related mortality in hematopoietic stem cell transplantation (HSCT) patients. Mixed infections and multiple organ involvement have been reported in these patients. Here, we report a case of mixed Aspergillus and Mucorales infection involving the lungs, brain, spleen and bone in a HSCT patient with relapsed acute myeloid leukemia, who finally improved with triple antifungal therapy and neurosurgical evacuation of brain abscesses. She was put on lifelong secondary prophylaxis with posaconazole with excellent compliance and no sign of toxicity despite over 10 years of drug administration. Serial galactomannan measurements and positron emission tomography/computed tomography were used and were helpful for disease activity monitoring. This is an instructive case of long-term survival after a severe combined mould infection.
650		4	\|a Hematopoietic stem cell transplant
650		4	\|a AML
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650		4	\|a Toxicity
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700	1		\|a Anderlini, Paolo \|4 aut
700	1		\|a Fuller, Gregory N. \|4 aut
700	1		\|a Kontoyiannis, Dimitrios P. \|4 aut
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A Long-Term Survivor of Disseminated Aspergillus and Mucorales Infection: An Instructive Case

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