Details der Publikation - Primordial follicle assembly was regulated by notch signaling pathway in the mice

Primordial follicle assembly was regulated by notch signaling pathway in the mice

Abstract Notch signaling pathway, a highly conserved cell signaling system, exists in most multicellular organisms. The objective of this study was to examine Notch signaling pathway in germ cell cyst breakdown and primordial follicle formation. The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01). Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles. Down-regulated mRNA expression of specific genes including Lhx8, Figla, Sohlh2 and Nobox, were also observed. The percentages of female germ cells in germ cell cysts and primordial follicles were counted after culture of newborn ovaries for 3 days in vitro. The result showed female germ cells in cysts was remarkably up-regulated while as the oocytes in primordial follicles was significantly down-regulated (P < 0.05). In conclusion, Notch signaling pathway may regulate the formation of primordial follicle in mice..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	Molecular biology reports - 41(2014), 3 vom: 16. Jan., Seite 1891-1899

Sprache:	Englisch

Beteiligte Personen:	Chen, Chun-Lei [VerfasserIn] Fu, Xia-Fei [VerfasserIn] Wang, Lin-Qing [VerfasserIn] Wang, Jun-Jie [VerfasserIn] Ma, Hua-Gang [VerfasserIn] Cheng, Shun-Feng [VerfasserIn] Hou, Zhu-Mei [VerfasserIn] Ma, Jin-Mei [VerfasserIn] Quan, Guo-Bo [VerfasserIn] Shen, Wei [VerfasserIn] Li, Lan [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	42.13$jMolekularbiologie
Themen:	Lhx8 Nobox Notch Primordial follicle

Anmerkungen:	© Springer Science+Business Media Dordrecht 2014

doi:	10.1007/s11033-014-3038-4

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2081394138

Internformat


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520			\|a Abstract Notch signaling pathway, a highly conserved cell signaling system, exists in most multicellular organisms. The objective of this study was to examine Notch signaling pathway in germ cell cyst breakdown and primordial follicle formation. The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01). Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles. Down-regulated mRNA expression of specific genes including Lhx8, Figla, Sohlh2 and Nobox, were also observed. The percentages of female germ cells in germ cell cysts and primordial follicles were counted after culture of newborn ovaries for 3 days in vitro. The result showed female germ cells in cysts was remarkably up-regulated while as the oocytes in primordial follicles was significantly down-regulated (P < 0.05). In conclusion, Notch signaling pathway may regulate the formation of primordial follicle in mice.
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Primordial follicle assembly was regulated by notch signaling pathway in the mice

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