Details der Publikation - Toxic effects of polychlorinated biphenyls on cardiac development in zebrafish

Toxic effects of polychlorinated biphenyls on cardiac development in zebrafish

Abstract Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that may pose significant health-risks to various organisms including humans. Although the mixed PCB Aroclor 1254 is widespread in the environment, its potential toxic effect on heart development and the mechanism underlying its developmental toxicity have not been previously studied. Here, we used the zebrafish as a toxicogenomic model to examine the effects of Aroclor 1254 on heart development. We found that PCB exposure during zebrafish development induced heart abnormalities including pericardial edema and cardiac looping defects. Further malformations of the zebrafish embryo were observed and death of the larvae occurred in a time- and dose-dependent manner. Our mechanistic studies revealed that abnormalities in the arylhydrocarbon receptor, Wnt and retinoic acid signaling pathways may underlie the effects of PCBs on zebrafish heart development. Interestingly, co-administration of Aroclor 1254 and diethylaminobenzaldehyde, an inhibitor of retinaldehyde dehydrogenase, partially rescued the toxic effects of PCBs on zebrafish heart development. In conclusion, PCBs can induce developmental defects in the zebrafish heart, which may be mediated by abnormal RA signaling..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	Molecular biology reports - 41(2014), 12 vom: 28. Aug., Seite 7973-7983

Sprache:	Englisch

Beteiligte Personen:	Li, Mengmeng [VerfasserIn] Wang, Xuejie [VerfasserIn] Zhu, Jingai [VerfasserIn] Zhu, Shasha [VerfasserIn] Hu, Xiaoshan [VerfasserIn] Zhu, Chun [VerfasserIn] Guo, Xirong [VerfasserIn] Yu, Zhangbin [VerfasserIn] Han, Shuping [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	42.13$jMolekularbiologie
Themen:	Development Heart Polychlorinated biphenyls Signaling pathway Zebrafish

Anmerkungen:	© Springer Science+Business Media Dordrecht 2014

doi:	10.1007/s11033-014-3692-6

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2081392348

Internformat


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520			\|a Abstract Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that may pose significant health-risks to various organisms including humans. Although the mixed PCB Aroclor 1254 is widespread in the environment, its potential toxic effect on heart development and the mechanism underlying its developmental toxicity have not been previously studied. Here, we used the zebrafish as a toxicogenomic model to examine the effects of Aroclor 1254 on heart development. We found that PCB exposure during zebrafish development induced heart abnormalities including pericardial edema and cardiac looping defects. Further malformations of the zebrafish embryo were observed and death of the larvae occurred in a time- and dose-dependent manner. Our mechanistic studies revealed that abnormalities in the arylhydrocarbon receptor, Wnt and retinoic acid signaling pathways may underlie the effects of PCBs on zebrafish heart development. Interestingly, co-administration of Aroclor 1254 and diethylaminobenzaldehyde, an inhibitor of retinaldehyde dehydrogenase, partially rescued the toxic effects of PCBs on zebrafish heart development. In conclusion, PCBs can induce developmental defects in the zebrafish heart, which may be mediated by abnormal RA signaling.
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Toxic effects of polychlorinated biphenyls on cardiac development in zebrafish

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