Spectrum and mortality of opportunistic infections among HIV/AIDS patients in southwestern China
Abstract We describe the opportunistic infections (OIs) of HIV/AIDS to understand the spectrum, mortality, and frequency of multiple coinfected OIs among HIV/AIDS patients in southern China, where OIs are severe. We carried out a retrospective cohort study of hospitalized HIV-infected individuals at the Fourth People’s Hospital of Nanning, Guangxi, China, from Jan. 2011 to May. 2019. The chi-square test was used to analyze cross-infection; the Kaplan‒Meier analysis was used to compare mortality. A total of 12,612 HIV-infected patients were admitted to this cohort study. Among them, 8982 (71.2%) developed one or more OIs. The overall in-hospital mortality rate was 9.0%. Among the patients, 35.6% coinfected one OI, and 64.4% coinfected more than two OIs simultaneously. Almost half of the patients (60.6%) had CD4 + T-cell counts < 200 cells/μL. Pneumonia (39.8%), tuberculosis (35.3%), and candidiasis (28.8%) were the most common OIs. Coinfected cryptococcal meningitis and dermatitis are the most common combined OIs. The rate of anaemia (17.0%) was highest among those common HIV-associated complications. Multiple OIs are commonly found in hospitalized HIV/AIDS patients in southwestern China, which highlights the need for improved diagnosis and treatment..
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Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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Enthalten in: |
European journal of clinical microbiology & infectious diseases - 42(2022), 1 vom: 21. Nov., Seite 113-120 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Meng, Sirun [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
HIV/AIDS |
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RVK: |
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Anmerkungen: |
© The Author(s) 2022 |
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doi: |
10.1007/s10096-022-04528-y |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2080241591 |
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520 | |a Abstract We describe the opportunistic infections (OIs) of HIV/AIDS to understand the spectrum, mortality, and frequency of multiple coinfected OIs among HIV/AIDS patients in southern China, where OIs are severe. We carried out a retrospective cohort study of hospitalized HIV-infected individuals at the Fourth People’s Hospital of Nanning, Guangxi, China, from Jan. 2011 to May. 2019. The chi-square test was used to analyze cross-infection; the Kaplan‒Meier analysis was used to compare mortality. A total of 12,612 HIV-infected patients were admitted to this cohort study. Among them, 8982 (71.2%) developed one or more OIs. The overall in-hospital mortality rate was 9.0%. Among the patients, 35.6% coinfected one OI, and 64.4% coinfected more than two OIs simultaneously. Almost half of the patients (60.6%) had CD4 + T-cell counts < 200 cells/μL. Pneumonia (39.8%), tuberculosis (35.3%), and candidiasis (28.8%) were the most common OIs. Coinfected cryptococcal meningitis and dermatitis are the most common combined OIs. The rate of anaemia (17.0%) was highest among those common HIV-associated complications. Multiple OIs are commonly found in hospitalized HIV/AIDS patients in southwestern China, which highlights the need for improved diagnosis and treatment. | ||
650 | 4 | |a HIV/AIDS | |
650 | 4 | |a Spectrum | |
650 | 4 | |a Mortality | |
650 | 4 | |a Opportunistic infections | |
650 | 4 | |a Southwestern China | |
700 | 1 | |a Tang, Qiao |4 aut | |
700 | 1 | |a Xie, Zhiman |4 aut | |
700 | 1 | |a Wu, Nianning |4 aut | |
700 | 1 | |a Qin, Yingmei |4 aut | |
700 | 1 | |a Chen, Rongfeng |4 aut | |
700 | 1 | |a Chen, Xiaoyu |4 aut | |
700 | 1 | |a Chen, Xiu |4 aut | |
700 | 1 | |a Li, Yueqi |4 aut | |
700 | 1 | |a Shi, Minjuan |4 aut | |
700 | 1 | |a Ye, Li |4 aut | |
700 | 1 | |a Liang, Hao |4 aut | |
700 | 1 | |a Jiang, Junjun |0 (orcid)0000-0003-4905-9348 |4 aut | |
700 | 1 | |a Zhou, Bo |4 aut | |
700 | 1 | |a Lin, Jianyan |4 aut | |
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