Sexual behavior and medication adherence in men who have sex with men participating in a pre-exposure prophylaxis study of combinations of Maraviroc, Tenofovir Disoproxil Fumarate and/or Emtricitabine (HPTN 069/ACTG 5305)
Abstract HPTN 069/ACTG 5305 was designed to evaluate potential new PrEP regimens that included maraviroc, tenofovir disoproxil fumarate, and/or emtricitabine. The current analyses assessed antiretroviral (ARV) plasma concentrations in relation to sexual behavior in 224 cisgender men who have sex with men and 2 transgender women at risk for HIV. Poisson generalized estimating equations (GEE) regression were used to test for associations between self-reported sexual behavior, sociodemographic, behavioral variables, and study drug levels The median (IQR) age was 30 [25, 37] years old; 48.2% had completed college; 27.4% were Black and 21.7% Latino. At weeks 24 and 48, one third of participants reported condomless anal sex (CAS) in the prior month with more than one partner. CAS was associated with daily ARV drug use ($ χ^{2} $ = 12.64, p = 0.002). Older individuals and those with greater education were more likely to ingest ARV drugs daily ($ χ^{2} $ = 9.36, p = 0.009 and $ χ^{2} $ = 8.63, p = 0.013, respectively), while neither race nor ethnicity was associated with daily ARV drug use. Participants who reported recent condomless anal sex and/or advanced education had higher rates of daily ARV drug use. These data support the need for ongoing adherence counseling in clinical trials of new PrEP modalities..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
---|---|
Enthalten in: |
Aids and behavior - 26(2022), 12 vom: 10. Juni, Seite 4107-4114 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mayer, Kenneth H. [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
Themen: |
---|
Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 |
---|
doi: |
10.1007/s10461-022-03736-z |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC207992866X |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | OLC207992866X | ||
003 | DE-627 | ||
005 | 20230519012400.0 | ||
007 | tu | ||
008 | 230131s2022 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s10461-022-03736-z |2 doi | |
035 | |a (DE-627)OLC207992866X | ||
035 | |a (DE-He213)s10461-022-03736-z-p | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q VZ |
100 | 1 | |a Mayer, Kenneth H. |e verfasserin |0 (orcid)0000-0001-7460-733X |4 aut | |
245 | 1 | 0 | |a Sexual behavior and medication adherence in men who have sex with men participating in a pre-exposure prophylaxis study of combinations of Maraviroc, Tenofovir Disoproxil Fumarate and/or Emtricitabine (HPTN 069/ACTG 5305) |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 | ||
520 | |a Abstract HPTN 069/ACTG 5305 was designed to evaluate potential new PrEP regimens that included maraviroc, tenofovir disoproxil fumarate, and/or emtricitabine. The current analyses assessed antiretroviral (ARV) plasma concentrations in relation to sexual behavior in 224 cisgender men who have sex with men and 2 transgender women at risk for HIV. Poisson generalized estimating equations (GEE) regression were used to test for associations between self-reported sexual behavior, sociodemographic, behavioral variables, and study drug levels The median (IQR) age was 30 [25, 37] years old; 48.2% had completed college; 27.4% were Black and 21.7% Latino. At weeks 24 and 48, one third of participants reported condomless anal sex (CAS) in the prior month with more than one partner. CAS was associated with daily ARV drug use ($ χ^{2} $ = 12.64, p = 0.002). Older individuals and those with greater education were more likely to ingest ARV drugs daily ($ χ^{2} $ = 9.36, p = 0.009 and $ χ^{2} $ = 8.63, p = 0.013, respectively), while neither race nor ethnicity was associated with daily ARV drug use. Participants who reported recent condomless anal sex and/or advanced education had higher rates of daily ARV drug use. These data support the need for ongoing adherence counseling in clinical trials of new PrEP modalities. | ||
650 | 4 | |a PrEP | |
650 | 4 | |a Tenofovir | |
650 | 4 | |a Maraviroc | |
650 | 4 | |a MSM | |
650 | 4 | |a HIV prevention | |
700 | 1 | |a Yuhas, Krista |4 aut | |
700 | 1 | |a Amico, K. Rivet |4 aut | |
700 | 1 | |a Wilkin, Timothy |4 aut | |
700 | 1 | |a Landovitz, Raphael J. |4 aut | |
700 | 1 | |a Richardson, Paul |4 aut | |
700 | 1 | |a Marzinke, Mark A. |4 aut | |
700 | 1 | |a Hendrix, Craig . W |4 aut | |
700 | 1 | |a Eshleman, Susan H. |4 aut | |
700 | 1 | |a Cottle, Leslie M. |4 aut | |
700 | 1 | |a Marcus, Cheryl |4 aut | |
700 | 1 | |a Chege, Wairimu |4 aut | |
700 | 1 | |a Rinehart, Alex R. |4 aut | |
700 | 1 | |a Rooney, James F. |4 aut | |
700 | 1 | |a Andrew, Philip |4 aut | |
700 | 1 | |a Salata, Robert A. |4 aut | |
700 | 1 | |a Magnus, Manya |4 aut | |
700 | 1 | |a Farley, Jason E. |4 aut | |
700 | 1 | |a Liu, Albert Y. |4 aut | |
700 | 1 | |a Frank, Ian |4 aut | |
700 | 1 | |a Ho, Ken |4 aut | |
700 | 1 | |a Santana, Jorge |4 aut | |
700 | 1 | |a Stekler, Joanne D. |4 aut | |
700 | 1 | |a Chen, Ying Q. |4 aut | |
700 | 1 | |a McCauley, Marybeth |4 aut | |
700 | 1 | |a Gulick, Roy M. |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Aids and behavior |d Springer US, 1997 |g 26(2022), 12 vom: 10. Juni, Seite 4107-4114 |w (DE-627)216697107 |w (DE-600)1339885-4 |w (DE-576)9216697105 |x 1090-7165 |7 nnns |
773 | 1 | 8 | |g volume:26 |g year:2022 |g number:12 |g day:10 |g month:06 |g pages:4107-4114 |
856 | 4 | 1 | |u https://doi.org/10.1007/s10461-022-03736-z |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a SSG-OLC-PHA | ||
912 | |a SSG-OLC-DE-84 | ||
912 | |a GBV_ILN_11 | ||
951 | |a AR | ||
952 | |d 26 |j 2022 |e 12 |b 10 |c 06 |h 4107-4114 |