Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs
Abstract Kojic acid (KA) is a natural product containing 3-hydroxy-4-pyranone scaffold. It is produced by various aerobic microorganisms such as Aspergillus and Penicillium species. Since this bioactive compound can inhibit tyrosinase enzyme, it has been mainly used as a whitening agent in cosmetics. KA is a polyfunctional heterocycle providing a potential intermediate for the design and synthesis of new biologically active compounds. Numerous studies demonstrated that KA-derived compounds have significant antibacterial, antifungal, anticancer, anticonvulsant, anti-Alzheimer’s disease and metal chelating activities. In this review, we have described diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs. Modification of the natural product kojic acid has been considered for new lead generation with diverse biological activities..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
---|---|
Enthalten in: |
Medicinal chemistry research - 31(2022), 11 vom: 05. Sept., Seite 1842-1861 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Emami, Saeed [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
Themen: |
4-Pyranone |
---|
Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
---|
doi: |
10.1007/s00044-022-02954-3 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC2079612999 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | OLC2079612999 | ||
003 | DE-627 | ||
005 | 20230518070656.0 | ||
007 | tu | ||
008 | 221221s2022 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s00044-022-02954-3 |2 doi | |
035 | |a (DE-627)OLC2079612999 | ||
035 | |a (DE-He213)s00044-022-02954-3-p | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 540 |a 610 |q VZ |
084 | |a 15,3 |2 ssgn | ||
084 | |a PHARM |q DE-84 |2 fid | ||
100 | 1 | |a Emami, Saeed |e verfasserin |0 (orcid)0000-0003-1665-6621 |4 aut | |
245 | 1 | 0 | |a Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
520 | |a Abstract Kojic acid (KA) is a natural product containing 3-hydroxy-4-pyranone scaffold. It is produced by various aerobic microorganisms such as Aspergillus and Penicillium species. Since this bioactive compound can inhibit tyrosinase enzyme, it has been mainly used as a whitening agent in cosmetics. KA is a polyfunctional heterocycle providing a potential intermediate for the design and synthesis of new biologically active compounds. Numerous studies demonstrated that KA-derived compounds have significant antibacterial, antifungal, anticancer, anticonvulsant, anti-Alzheimer’s disease and metal chelating activities. In this review, we have described diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs. Modification of the natural product kojic acid has been considered for new lead generation with diverse biological activities. | ||
650 | 4 | |a Kojic acid | |
650 | 4 | |a 4-Pyranone | |
650 | 4 | |a Bioactive compounds | |
650 | 4 | |a Drug design | |
650 | 4 | |a Lead generation | |
700 | 1 | |a Ahmadi, Reza |4 aut | |
700 | 1 | |a Ahadi, Hamideh |4 aut | |
700 | 1 | |a Ashooriha, Morteza |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Medicinal chemistry research |d Springer US, 1991 |g 31(2022), 11 vom: 05. Sept., Seite 1842-1861 |w (DE-627)170853772 |w (DE-600)1116702-6 |w (DE-576)032853815 |x 1054-2523 |7 nnns |
773 | 1 | 8 | |g volume:31 |g year:2022 |g number:11 |g day:05 |g month:09 |g pages:1842-1861 |
856 | 4 | 1 | |u https://doi.org/10.1007/s00044-022-02954-3 |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a FID-PHARM | ||
912 | |a SSG-OLC-PHA | ||
912 | |a SSG-OLC-DE-84 | ||
912 | |a SSG-OPC-PHA | ||
951 | |a AR | ||
952 | |d 31 |j 2022 |e 11 |b 05 |c 09 |h 1842-1861 |