Green and one-pot synthesis of novel amidoalkyl naphthols using triethanolammonium acetate [($ OHCH_{2} $$ CH_{2} $)3NH][OAc]) ionic liquid and their anti-H.pylori activity
Abstract Nearly half of the world's population have been infected with Helicobacter pylori (H. pylori) which is known as the main cause of chronic gastritis, duodenal ulcer illness as well as stomach carcinoma. In this work, an efficient, one-pot synthesis of amidoalkyl naphthol derivatives and their in vitro anti-Helicobacter pylori activity are reported. The reaction proceeds via multi-component condensation of 2-naphthol, (hetero) aromatic aldehydes and urea/thiourea/acetamide/2-aminothiazole/4-nitrothiazol-2-amine/2-aminopyridine under solvent-free condition. This protocol includes some salient features, such as using triethanolammonium acetate ([$ OHCH_{2} $$ CH_{2} $)3NH][OAc]) ionic liquid as a green, clean and reusable catalyst, high yields, no column chromatography, and low cost. By comparing the inhibition zone of the target compounds, 6e and 6j could be considered as the best anti-helicobacter agent..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Research on chemical intermediates - 48(2022), 10 vom: 19. Aug., Seite 4049-4062 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Manavi, Mohammad Amin [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
1-amidoalkyl-2-naphthol |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s11164-022-04803-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC2079560980 |
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| 520 | |a Abstract Nearly half of the world's population have been infected with Helicobacter pylori (H. pylori) which is known as the main cause of chronic gastritis, duodenal ulcer illness as well as stomach carcinoma. In this work, an efficient, one-pot synthesis of amidoalkyl naphthol derivatives and their in vitro anti-Helicobacter pylori activity are reported. The reaction proceeds via multi-component condensation of 2-naphthol, (hetero) aromatic aldehydes and urea/thiourea/acetamide/2-aminothiazole/4-nitrothiazol-2-amine/2-aminopyridine under solvent-free condition. This protocol includes some salient features, such as using triethanolammonium acetate ([$ OHCH_{2} $$ CH_{2} $)3NH][OAc]) ionic liquid as a green, clean and reusable catalyst, high yields, no column chromatography, and low cost. By comparing the inhibition zone of the target compounds, 6e and 6j could be considered as the best anti-helicobacter agent. | ||
| 650 | 4 | |a 1-amidoalkyl-2-naphthol | |
| 650 | 4 | |a Multi-component reaction | |
| 650 | 4 | |a Green synthesis | |
| 650 | 4 | |a Solvent-free condition | |
| 700 | 1 | |a Fathian Nasab, Mohammad Hosein |4 aut | |
| 700 | 1 | |a Dashti, Fatemeh |4 aut | |
| 700 | 1 | |a Moghimi, Setareh |4 aut | |
| 700 | 1 | |a Saniee, Parastoo |4 aut | |
| 700 | 1 | |a Pouramiri, Behjat |4 aut | |
| 700 | 1 | |a Foroumadi, Alireza |4 aut | |
| 700 | 1 | |a Pirali-Hamedani, Morteza |4 aut | |
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