Chronic kidney disease and clinical outcomes in patients with COVID-19 in Japan
Background Identifying predictive factors for coronavirus disease 2019 (COVID-19) is crucial for risk stratification and intervention. Kidney dysfunction contributes to the severity of various infectious diseases. However, the association between on-admission kidney dysfunction and the clinical outcome in COVID-19 patients is unclear. Methods This study was a multicenter retrospective observational cohort study of COVID-19 patients, diagnosed by polymerase chain reaction. We retrospectively analyzed 500 COVID-19 patients (mean age: 51 ± 19 years) admitted to eight hospitals in Japan. Kidney dysfunction was defined as a reduced estimated glomerular filtration rate (< 60 mL/min/1.73 $ m^{2} $) or proteinuria (≥ 1 + dipstick proteinuria) on admission. The primary composite outcome included in-hospital death, extracorporeal membrane oxygenation, mechanical ventilation (invasive and noninvasive methods), and intensive care unit (ICU) admission. Results Overall, 171 (34.2%) patients presented with on-admission kidney dysfunction, and the primary composite outcome was observed in 60 (12.0%) patients. Patients with kidney dysfunction showed higher rates of in-hospital death (12.3 vs. 1.2%), mechanical ventilation (13.5 vs. 4.0%), and ICU admission (18.1 vs. 5.2%) than those without it. Categorical and multivariate regression analyses revealed that kidney dysfunction was substantially associated with the primary composite outcome. Thus, on-admission kidney dysfunction was common in COVID-19 patients. Furthermore, it correlated significantly and positively with COVID-19 severity and mortality. Conclusions On-admission kidney dysfunction was associated with disease severity and poor short-term prognosis in patients with COVID-19. Thus, on-admission kidney dysfunction has the potential to stratify risks in COVID-19 patients..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
---|---|
Enthalten in: |
Clinical and experimental nephrology - 26(2022), 10 vom: 03. Juni, Seite 974-981 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Sato, Ryosuke [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
Themen: |
---|
Anmerkungen: |
© The Author(s), under exclusive licence to The Japanese Society of Nephrology 2022 |
---|
doi: |
10.1007/s10157-022-02240-x |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC2079549324 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | OLC2079549324 | ||
003 | DE-627 | ||
005 | 20230516123535.0 | ||
007 | tu | ||
008 | 221220s2022 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s10157-022-02240-x |2 doi | |
035 | |a (DE-627)OLC2079549324 | ||
035 | |a (DE-He213)s10157-022-02240-x-p | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q VZ |
100 | 1 | |a Sato, Ryosuke |e verfasserin |4 aut | |
245 | 1 | 0 | |a Chronic kidney disease and clinical outcomes in patients with COVID-19 in Japan |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a © The Author(s), under exclusive licence to The Japanese Society of Nephrology 2022 | ||
520 | |a Background Identifying predictive factors for coronavirus disease 2019 (COVID-19) is crucial for risk stratification and intervention. Kidney dysfunction contributes to the severity of various infectious diseases. However, the association between on-admission kidney dysfunction and the clinical outcome in COVID-19 patients is unclear. Methods This study was a multicenter retrospective observational cohort study of COVID-19 patients, diagnosed by polymerase chain reaction. We retrospectively analyzed 500 COVID-19 patients (mean age: 51 ± 19 years) admitted to eight hospitals in Japan. Kidney dysfunction was defined as a reduced estimated glomerular filtration rate (< 60 mL/min/1.73 $ m^{2} $) or proteinuria (≥ 1 + dipstick proteinuria) on admission. The primary composite outcome included in-hospital death, extracorporeal membrane oxygenation, mechanical ventilation (invasive and noninvasive methods), and intensive care unit (ICU) admission. Results Overall, 171 (34.2%) patients presented with on-admission kidney dysfunction, and the primary composite outcome was observed in 60 (12.0%) patients. Patients with kidney dysfunction showed higher rates of in-hospital death (12.3 vs. 1.2%), mechanical ventilation (13.5 vs. 4.0%), and ICU admission (18.1 vs. 5.2%) than those without it. Categorical and multivariate regression analyses revealed that kidney dysfunction was substantially associated with the primary composite outcome. Thus, on-admission kidney dysfunction was common in COVID-19 patients. Furthermore, it correlated significantly and positively with COVID-19 severity and mortality. Conclusions On-admission kidney dysfunction was associated with disease severity and poor short-term prognosis in patients with COVID-19. Thus, on-admission kidney dysfunction has the potential to stratify risks in COVID-19 patients. | ||
650 | 4 | |a Kidney dysfunction | |
650 | 4 | |a Clinical outcome | |
650 | 4 | |a COVID-19 | |
700 | 1 | |a Matsuzawa, Yasushi |4 aut | |
700 | 1 | |a Ogawa, Hisao |4 aut | |
700 | 1 | |a Kimura, Kazuo |4 aut | |
700 | 1 | |a Tsuboi, Nobuo |4 aut | |
700 | 1 | |a Yokoo, Takashi |4 aut | |
700 | 1 | |a Okada, Hirokazu |4 aut | |
700 | 1 | |a Konishi, Masaaki |4 aut | |
700 | 1 | |a Kirigaya, Jin |4 aut | |
700 | 1 | |a Fukui, Kazuki |4 aut | |
700 | 1 | |a Tsukahara, Kengo |4 aut | |
700 | 1 | |a Shimizu, Hiroyuki |4 aut | |
700 | 1 | |a Iwabuchi, Keisuke |4 aut | |
700 | 1 | |a Yamada, Yu |4 aut | |
700 | 1 | |a Saka, Kenichiro |4 aut | |
700 | 1 | |a Takeuchi, Ichiro |4 aut | |
700 | 1 | |a Kashihara, Naoki |4 aut | |
700 | 1 | |a Tamura, Kouichi |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Clinical and experimental nephrology |d Springer Nature Singapore, 1997 |g 26(2022), 10 vom: 03. Juni, Seite 974-981 |w (DE-627)216532361 |w (DE-600)1338768-6 |x 1342-1751 |7 nnns |
773 | 1 | 8 | |g volume:26 |g year:2022 |g number:10 |g day:03 |g month:06 |g pages:974-981 |
856 | 4 | 1 | |u https://doi.org/10.1007/s10157-022-02240-x |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a SSG-OLC-PHA | ||
912 | |a SSG-OLC-DE-84 | ||
951 | |a AR | ||
952 | |d 26 |j 2022 |e 10 |b 03 |c 06 |h 974-981 |