Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women: a population-based, randomized-sampling, cross-sectional study
Summary In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high. Purpose To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study. Methods The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant’s semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant’s score 1–3 and were analyzed using descriptive statistics. Results A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran–Armitage test p < 0.0001) and was significantly higher in women aged ≥ 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age ≥ 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria. Conclusion VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis..
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Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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Enthalten in: |
Archives of osteoporosis - 17(2022), 1 vom: 07. Sept. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Xia, Weibo [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
Community-dwelling |
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Anmerkungen: |
© The Author(s) 2022 |
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doi: |
10.1007/s11657-022-01158-x |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2079478303 |
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520 | |a Summary In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high. Purpose To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study. Methods The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant’s semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant’s score 1–3 and were analyzed using descriptive statistics. Results A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran–Armitage test p < 0.0001) and was significantly higher in women aged ≥ 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age ≥ 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria. Conclusion VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis. | ||
650 | 4 | |a Prevalent vertebral fractures | |
650 | 4 | |a Osteoporosis | |
650 | 4 | |a Randomized sampling | |
650 | 4 | |a Postmenopausal women | |
650 | 4 | |a Community-dwelling | |
700 | 1 | |a Liu, Qiang |4 aut | |
700 | 1 | |a Lv, Jinhan |4 aut | |
700 | 1 | |a Zhang, Zhenlin |4 aut | |
700 | 1 | |a Wu, Wen |4 aut | |
700 | 1 | |a Xie, Zhongjian |4 aut | |
700 | 1 | |a Chen, Jianting |4 aut | |
700 | 1 | |a He, Liang |4 aut | |
700 | 1 | |a Dong, Jian |4 aut | |
700 | 1 | |a Hu, Zhenming |4 aut | |
700 | 1 | |a Lin, Qiang |4 aut | |
700 | 1 | |a Yu, Wei |4 aut | |
700 | 1 | |a Wei, Fang |4 aut | |
700 | 1 | |a Wang, Jue |4 aut | |
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