Assessing the Efficacy and Outcomes Following Irrigation with Streptokinase Versus Hydrogen Peroxide in Necrotizing Pancreatitis: A Randomized Pilot Study
Background Percutaneous catheter drainage (PCD’s) are prone to blockage because of necrosum. To improve the efficacy of PCD, necrolytic agents have been used. The present study compared the use of Streptokinase with $ H_{2} $$ O_{2} $ in saline irrigation. Materials and Methods This is a single-center randomized pilot study (from July 2018 to Dec 2019). Patients with infected pancreatic necrosis not showing response to PCD and saline irrigation were included in the study. Patients received either Streptokinase (Streptokinase group 50,000 IU in 100 ml normal saline) or 3% $ H_{2} $$ O_{2} $ (3% $ H_{2} $$ O_{2} $ in 100 ml normal saline in 1:10 dilution). Primary endpoints were the need for surgery and mortality while secondary endpoints were hospital stay and complications attributable to necrolytic agents. Results There were 30 patients in the study, 15 in each arm. Organ failure was seen in 23 (76.6%), single organ failure was present in 11 (47%), and multi-organ failure in 12 (53%). Bleeding complications (20% in $ H_{2} $$ O_{2} $ vs 6.6% in Streptokinase), need for surgery (73% in $ H_{2} $$ O_{2} $ vs 33.3% in Streptokinase) and mortality (60% in $ H_{2} $$ O_{2} $ vs 33% in Streptokinase) were higher in $ H_{2} $$ O_{2} $ group but the difference was not significant statistically. Post-irrigation hospital stay was lesser in the Streptokinase group compared to $ H_{2} $$ O_{2} $ group but the difference did not reach statistical significance (14.1 ± 7.7 vs 19.2 ± 11.7, p = 0.09) Conclusions Streptokinase irrigation led to a trend for reduced need for necrosectomy and mortality. $ H_{2} $$ O_{2} $ group had more bleeding $ complications_{.} $ Post-irrigation hospital stay was lesser in Streptokinase group..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
|---|---|
| Enthalten in: |
Digestive diseases and sciences - 67(2021), 8 vom: 17. Aug., Seite 4146-4153 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bhargava, M. Venu [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Irrigation of cavity with hydrogen peroxide |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
|---|
| doi: |
10.1007/s10620-021-07201-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2079159585 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2079159585 | ||
| 003 | DE-627 | ||
| 005 | 20230518094643.0 | ||
| 007 | tu | ||
| 008 | 221220s2021 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10620-021-07201-0 |2 doi | |
| 035 | |a (DE-627)OLC2079159585 | ||
| 035 | |a (DE-He213)s10620-021-07201-0-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Bhargava, M. Venu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessing the Efficacy and Outcomes Following Irrigation with Streptokinase Versus Hydrogen Peroxide in Necrotizing Pancreatitis: A Randomized Pilot Study |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 | ||
| 520 | |a Background Percutaneous catheter drainage (PCD’s) are prone to blockage because of necrosum. To improve the efficacy of PCD, necrolytic agents have been used. The present study compared the use of Streptokinase with $ H_{2} $$ O_{2} $ in saline irrigation. Materials and Methods This is a single-center randomized pilot study (from July 2018 to Dec 2019). Patients with infected pancreatic necrosis not showing response to PCD and saline irrigation were included in the study. Patients received either Streptokinase (Streptokinase group 50,000 IU in 100 ml normal saline) or 3% $ H_{2} $$ O_{2} $ (3% $ H_{2} $$ O_{2} $ in 100 ml normal saline in 1:10 dilution). Primary endpoints were the need for surgery and mortality while secondary endpoints were hospital stay and complications attributable to necrolytic agents. Results There were 30 patients in the study, 15 in each arm. Organ failure was seen in 23 (76.6%), single organ failure was present in 11 (47%), and multi-organ failure in 12 (53%). Bleeding complications (20% in $ H_{2} $$ O_{2} $ vs 6.6% in Streptokinase), need for surgery (73% in $ H_{2} $$ O_{2} $ vs 33.3% in Streptokinase) and mortality (60% in $ H_{2} $$ O_{2} $ vs 33% in Streptokinase) were higher in $ H_{2} $$ O_{2} $ group but the difference was not significant statistically. Post-irrigation hospital stay was lesser in the Streptokinase group compared to $ H_{2} $$ O_{2} $ group but the difference did not reach statistical significance (14.1 ± 7.7 vs 19.2 ± 11.7, p = 0.09) Conclusions Streptokinase irrigation led to a trend for reduced need for necrosectomy and mortality. $ H_{2} $$ O_{2} $ group had more bleeding $ complications_{.} $ Post-irrigation hospital stay was lesser in Streptokinase group. | ||
| 650 | 4 | |a Necrotizing pancreatitis | |
| 650 | 4 | |a PCD failure | |
| 650 | 4 | |a Irrigation with streptokinase | |
| 650 | 4 | |a Irrigation of cavity with hydrogen peroxide | |
| 700 | 1 | |a Rana, Surinder Singh |4 aut | |
| 700 | 1 | |a Gorsi, Ujjwal |4 aut | |
| 700 | 1 | |a Kang, Mandeep |4 aut | |
| 700 | 1 | |a Gupta, Rajesh |0 (orcid)0000-0002-6585-1725 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Digestive diseases and sciences |d Springer US, 1979 |g 67(2021), 8 vom: 17. Aug., Seite 4146-4153 |w (DE-627)129894036 |w (DE-600)304250-9 |w (DE-576)015213218 |x 0163-2116 |7 nnns |
| 773 | 1 | 8 | |g volume:67 |g year:2021 |g number:8 |g day:17 |g month:08 |g pages:4146-4153 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s10620-021-07201-0 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 951 | |a AR | ||
| 952 | |d 67 |j 2021 |e 8 |b 17 |c 08 |h 4146-4153 | ||