Recurrent atrial arrhythmia in a randomised controlled trial comparing contact force–guided and contact force–blinded ablation for typical atrial flutter
Background Contact force (CF)–guided catheter ablation (CA) is a novel technology developed to improve efficacy and reduce complications. In a randomised controlled trial (RCT), we previously documented that after 3 months, rate of persistent conduction block was similar with and without using CF while performing CA for typical atrial flutter (AFL). Clinical effect of CF on recurrent arrhythmia is unknown. Our objective is to study recurrent atrial arrhythmia during 12-month follow-up in a RCT investigating whether CF-guided CA for typical AFL is superior to CF-blinded CA. Methods Patients were randomised 1:1 to CA guided by CF (intervention group) or blinded to CF (control group). After 12 months, patients attended clinical check-up preceded by a 5-day ambulatory Holter monitor recording. Primary outcome was any recurrent atrial arrhythmia ≥ 30 s within 12 months and documented in 12-lead ECG or Holter monitor recording. Results We included 156 patients, four patients withdrew consent and two died during follow-up. Thus, 150 patients were included in final analysis. Recurrent arrhythmia was detected in 36 of 77 (47%) patients in the intervention group, and 32 of 73 patients (44%) in the control group (p = 0.51). Atrial fibrillation was detected in 23 (30%) and 29 (40%) patients in the intervention and control groups respectively. AFL was detected in 11 (14%) and 5 (7%) patients in the intervention and control groups respectively. Conclusions Contact force–guided ablation for typical atrial flutter does not reduce recurrent atrial arrhythmia after 12-month follow-up as compared with ablation blinded for contact force. Graphical abstract.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
|---|---|
| Enthalten in: |
Journal of interventional cardiac electrophysiology - 63(2022), 3 vom: 13. Jan., Seite 699-707 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Giehm-Reese, Mikkel [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Catheter ablation |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 |
|---|
| doi: |
10.1007/s10840-022-01119-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2078802522 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2078802522 | ||
| 003 | DE-627 | ||
| 005 | 20230511070504.0 | ||
| 007 | tu | ||
| 008 | 221220s2022 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10840-022-01119-x |2 doi | |
| 035 | |a (DE-627)OLC2078802522 | ||
| 035 | |a (DE-He213)s10840-022-01119-x-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Giehm-Reese, Mikkel |e verfasserin |0 (orcid)0000-0001-9951-7998 |4 aut | |
| 245 | 1 | 0 | |a Recurrent atrial arrhythmia in a randomised controlled trial comparing contact force–guided and contact force–blinded ablation for typical atrial flutter |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 | ||
| 520 | |a Background Contact force (CF)–guided catheter ablation (CA) is a novel technology developed to improve efficacy and reduce complications. In a randomised controlled trial (RCT), we previously documented that after 3 months, rate of persistent conduction block was similar with and without using CF while performing CA for typical atrial flutter (AFL). Clinical effect of CF on recurrent arrhythmia is unknown. Our objective is to study recurrent atrial arrhythmia during 12-month follow-up in a RCT investigating whether CF-guided CA for typical AFL is superior to CF-blinded CA. Methods Patients were randomised 1:1 to CA guided by CF (intervention group) or blinded to CF (control group). After 12 months, patients attended clinical check-up preceded by a 5-day ambulatory Holter monitor recording. Primary outcome was any recurrent atrial arrhythmia ≥ 30 s within 12 months and documented in 12-lead ECG or Holter monitor recording. Results We included 156 patients, four patients withdrew consent and two died during follow-up. Thus, 150 patients were included in final analysis. Recurrent arrhythmia was detected in 36 of 77 (47%) patients in the intervention group, and 32 of 73 patients (44%) in the control group (p = 0.51). Atrial fibrillation was detected in 23 (30%) and 29 (40%) patients in the intervention and control groups respectively. AFL was detected in 11 (14%) and 5 (7%) patients in the intervention and control groups respectively. Conclusions Contact force–guided ablation for typical atrial flutter does not reduce recurrent atrial arrhythmia after 12-month follow-up as compared with ablation blinded for contact force. Graphical abstract | ||
| 650 | 4 | |a Catheter ablation | |
| 650 | 4 | |a Typical atrial flutter | |
| 650 | 4 | |a Recurrent arrhythmia | |
| 650 | 4 | |a Contact force | |
| 650 | 4 | |a Lesion size index | |
| 700 | 1 | |a Kronborg, Mads Brix |4 aut | |
| 700 | 1 | |a Lukac, Peter |4 aut | |
| 700 | 1 | |a Kristiansen, Steen Buus |4 aut | |
| 700 | 1 | |a Jensen, Henrik Kjærulf |4 aut | |
| 700 | 1 | |a Gerdes, Christian |4 aut | |
| 700 | 1 | |a Kristensen, Jens |4 aut | |
| 700 | 1 | |a Nielsen, Jan Møller |4 aut | |
| 700 | 1 | |a Nielsen, Jens Cosedis |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of interventional cardiac electrophysiology |d Springer US, 1997 |g 63(2022), 3 vom: 13. Jan., Seite 699-707 |w (DE-627)214101444 |w (DE-600)1329179-8 |w (DE-576)9214101442 |x 1383-875X |7 nnns |
| 773 | 1 | 8 | |g volume:63 |g year:2022 |g number:3 |g day:13 |g month:01 |g pages:699-707 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s10840-022-01119-x |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 951 | |a AR | ||
| 952 | |d 63 |j 2022 |e 3 |b 13 |c 01 |h 699-707 | ||