Details der Publikation - Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

Abstract Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimated cause of community-acquired invasive infections in Belgium..

Medienart:	Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	European journal of clinical microbiology & infectious diseases - 41(2022), 5 vom: 30. März, Seite 859-865

Sprache:	Englisch

Beteiligte Personen:	Anantharajah, Ahalieyah [VerfasserIn] Deltombe, Matthieu [VerfasserIn] de Barsy, Marie [VerfasserIn] Evrard, Stephanie [VerfasserIn] Denis, Olivier [VerfasserIn] Bogaerts, Pierre [VerfasserIn] Hallin, Marie [VerfasserIn] Miendje Deyi, Véronique Yvette [VerfasserIn] Pierard, Denis [VerfasserIn] Bruynseels, Peggy [VerfasserIn] Boelens, Jerina [VerfasserIn] Glupczynski, Youri [VerfasserIn] Huang, Te-Din [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Capsular serotype Hypermucoviscosity Hypervirulence Molecular epidemiology Whole genome sequencing

RVK:	RVK Klassifikation ELIB24 ELIB09

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022

doi:	10.1007/s10096-022-04438-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2078515574

Internformat


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520			\|a Abstract Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimated cause of community-acquired invasive infections in Belgium.
650		4	\|a Hypervirulence
650		4	\|a Hypermucoviscosity
650		4	\|a Capsular serotype
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700	1		\|a Deltombe, Matthieu \|4 aut
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700	1		\|a Denis, Olivier \|4 aut
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700	1		\|a Glupczynski, Youri \|4 aut
700	1		\|a Huang, Te-Din \|4 aut
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912			\|a GBV_ILN_150
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912			\|a GBV_ILN_161
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912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
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912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
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912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
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912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
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912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
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912			\|a GBV_ILN_2107
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912			\|a GBV_ILN_2110
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912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2134
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
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912			\|a GBV_ILN_2232
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912			\|a GBV_ILN_2507
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912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4046
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
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912			\|a GBV_ILN_4326
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912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
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Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

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