Imidazolium Based Surface Active Ionic Liquids: Promising Boosters to Enhance the Radical Scavenging and Antioxidant Activity of Conventional Surfactant Solubilised Quercetin
Surface Active Ionic Liquids (SAILs) are emerging as promising alternatives to conventional amphiphiles. Their unique specialties endow the SAIL/SAIL plus conventional surfactant based micellar/mixed micellar systems with unique solubilization, catalytic and electrocatalytic properties. Herein we demonstrate that as a partner of conventional surfactant based mixed micellar systems, imidazolium based SAILs significantly boost the radical scavenging activity (RSA) and antioxidant activity of water insoluble flavonoids. Specifically, we report the RSA and antioxidant activity kinetics of quercetin toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) in aqueous micellar media of SAIL, 1-Butyl-3-methyl-imidazolium dodecylsulfate (BMIMDS), its conventional anionic surfactant analogue-sodium dodecylsulfate (SDS), conventional nonionic surfactant-Brij56 and the variedly composed BMIMDS plus Brij56 mixed micellar solutions. The presented results clearly suggest that in comparison to the conventional micellar systems, the radical scavenging ability and activity of quercetin for DPPH is appreciably better in appropriately composed SAIL plus conventional surfactant mixed micellar systems. These results further suggest that the RSA of quercetin toward DPPH is a function of its aqueous phase to micellar phase partitioning, locus of solubilization and more importantly its orientation vis-a-vis the later within the micelles. The 1:1 Brij56 plus BMIMDS mixed micellar system seems to offer the best environs for the optimal RSA and kinetics for antioxidant activity of quercetin toward DPPH. The kinetic details and the mechanistic insights presented herein shall stimulate an intense research activity toward use of SAIL and SAIL based micellar systems as promising delivery systems for water insoluble flavonoids for their potential applications as pharmaceuticals and food ingredients. Graphic Abstract.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:152 |
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| Enthalten in: |
Catalysis letters - 152(2021), 5 vom: 24. Juli, Seite 1276-1285 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Butt, Fayaz Ahmad [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Antioxidant activity |
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| RVK: |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
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| doi: |
10.1007/s10562-021-03738-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Surface Active Ionic Liquids (SAILs) are emerging as promising alternatives to conventional amphiphiles. Their unique specialties endow the SAIL/SAIL plus conventional surfactant based micellar/mixed micellar systems with unique solubilization, catalytic and electrocatalytic properties. Herein we demonstrate that as a partner of conventional surfactant based mixed micellar systems, imidazolium based SAILs significantly boost the radical scavenging activity (RSA) and antioxidant activity of water insoluble flavonoids. Specifically, we report the RSA and antioxidant activity kinetics of quercetin toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) in aqueous micellar media of SAIL, 1-Butyl-3-methyl-imidazolium dodecylsulfate (BMIMDS), its conventional anionic surfactant analogue-sodium dodecylsulfate (SDS), conventional nonionic surfactant-Brij56 and the variedly composed BMIMDS plus Brij56 mixed micellar solutions. The presented results clearly suggest that in comparison to the conventional micellar systems, the radical scavenging ability and activity of quercetin for DPPH is appreciably better in appropriately composed SAIL plus conventional surfactant mixed micellar systems. These results further suggest that the RSA of quercetin toward DPPH is a function of its aqueous phase to micellar phase partitioning, locus of solubilization and more importantly its orientation vis-a-vis the later within the micelles. The 1:1 Brij56 plus BMIMDS mixed micellar system seems to offer the best environs for the optimal RSA and kinetics for antioxidant activity of quercetin toward DPPH. The kinetic details and the mechanistic insights presented herein shall stimulate an intense research activity toward use of SAIL and SAIL based micellar systems as promising delivery systems for water insoluble flavonoids for their potential applications as pharmaceuticals and food ingredients. Graphic Abstract | ||
| 650 | 4 | |a Quercetin | |
| 650 | 4 | |a Antioxidant activity | |
| 650 | 4 | |a Surface Active Ionic Liquid (SAIL) | |
| 650 | 4 | |a Mixed micelle | |
| 650 | 4 | |a Radical scavenging activity | |
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| 700 | 1 | |a Bhat, Parvaiz Ahmad |4 aut | |
| 700 | 1 | |a Bhat, Sajad Ahmad |4 aut | |
| 700 | 1 | |a Rather, Mudasir Ahmad |4 aut | |
| 700 | 1 | |a Rather, Ghulam Mohammad |4 aut | |
| 700 | 1 | |a Bhat, Mohsin Ahmad |4 aut | |
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