Quality of Life in Patients with Benign Non-Toxic Goiter After Surgical Intervention: A Systematic Review and Meta-Analysis
Background Prior studies evaluating health-related quality of life (HR-QoL) outcomes in patients undergoing surgery for benign non-toxic goiter have used different instruments and time points, leading to conflicting results. We sought to systematically review the differences in HR-QoL among patients with BNTG at baseline and 6 months after surgery, using exclusively the ThyPRO questionnaire. Methods A systematic search was performed using PubMed, Embase, Web of Science, Cochrane Central, CINAHL, and PsycINFO for papers reporting the assessment of HR-QoL utilizing ThyPRO. Data were meta-analyzed using a random-effects model, and pooled estimates were calculated using weighted mean differences (WMD) between baseline and 6 months after surgery. We assessed the quality and risk of bias of the studies using the Robins-I tool and previously published minimally important change (MIC) values to assess clinical significance. Results Six papers met the predefined inclusion criteria, describing a total of 496 patients. Meta-analysis demonstrated improved QoL in all thirteen domains of ThyPRO six months post-surgical intervention compared to baseline. Specifically, the largest improvement in QoL was seen in the domains of overall QoL, WMD −25.84 (95% CI −29.70, −21.98, p < 0.001, $ I^{2} $ = 23%), goiter symptoms, 23.96 (95% CI −30.29, −17.64, p < 0.001, $ I^{2} $ = 91%), and tiredness, −16.20 (95% CI −19.23, −13.16, p < 0.001, $ I^{2} $ = 3%). The differences in scores 9 of 13 domains were clinically significant based on MIC. Conclusions Disease-specific HR-QoL improved in all ThyPRO domains after surgery in patients with BNTG. Future studies of QoL in thyroid surgery patients will benefit from a standard questionnaire and improved reporting of covariates including complications to ensure comparability across studies..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
World journal of surgery - 46(2022), 5 vom: 24. Jan., Seite 1093-1104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chaves, Natalia [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Anmerkungen: |
© The Author(s) under exclusive licence to Société Internationale de Chirurgie 2022 |
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| doi: |
10.1007/s00268-022-06452-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2078376256 |
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| 520 | |a Background Prior studies evaluating health-related quality of life (HR-QoL) outcomes in patients undergoing surgery for benign non-toxic goiter have used different instruments and time points, leading to conflicting results. We sought to systematically review the differences in HR-QoL among patients with BNTG at baseline and 6 months after surgery, using exclusively the ThyPRO questionnaire. Methods A systematic search was performed using PubMed, Embase, Web of Science, Cochrane Central, CINAHL, and PsycINFO for papers reporting the assessment of HR-QoL utilizing ThyPRO. Data were meta-analyzed using a random-effects model, and pooled estimates were calculated using weighted mean differences (WMD) between baseline and 6 months after surgery. We assessed the quality and risk of bias of the studies using the Robins-I tool and previously published minimally important change (MIC) values to assess clinical significance. Results Six papers met the predefined inclusion criteria, describing a total of 496 patients. Meta-analysis demonstrated improved QoL in all thirteen domains of ThyPRO six months post-surgical intervention compared to baseline. Specifically, the largest improvement in QoL was seen in the domains of overall QoL, WMD −25.84 (95% CI −29.70, −21.98, p < 0.001, $ I^{2} $ = 23%), goiter symptoms, 23.96 (95% CI −30.29, −17.64, p < 0.001, $ I^{2} $ = 91%), and tiredness, −16.20 (95% CI −19.23, −13.16, p < 0.001, $ I^{2} $ = 3%). The differences in scores 9 of 13 domains were clinically significant based on MIC. Conclusions Disease-specific HR-QoL improved in all ThyPRO domains after surgery in patients with BNTG. Future studies of QoL in thyroid surgery patients will benefit from a standard questionnaire and improved reporting of covariates including complications to ensure comparability across studies. | ||
| 700 | 1 | |a Rodriguez, M. Juanita |4 aut | |
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| 700 | 1 | |a James, Benjamin C. |4 aut | |
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