Impact of postoperative radiotherapy on the outcomes of resected adrenocortical carcinoma—a real-world, population-based study
Objective To assess the impact of postoperative radiotherapy on the outcomes of resected adrenocortical carcinoma in a real-world setting. Methods The Surveillance, Epidemiology, and End Results Research Plus database was accessed, and patients with resected non-metastatic adrenocortical carcinoma diagnosed 2010–2015 were reviewed. Kaplan–Meier estimates and log-rank testing were used to examine the impact of postoperative radiotherapy on overall and cancer-specific survival. Multivariable Cox regression analysis was used to explore factors associated with overall and cancer-specific survival. Results A total of 294 patients were included in the final analysis, including 60 patients (20.4%) who received postoperative radiotherapy. Using Kaplan–Meier estimates, individuals who received postoperative radiotherapy have better overall survival (P = 0.002). Multivariable cox regression analysis showed that the following factors were associated with worse overall survival: older age (HR: 1.01; 95% CI: 1.00–1.03), male sex (HR for female sex versus male sex: 0.61; 95% CI: 0.43–0.85), and non-receipt of postoperative radiation therapy (HR: 2.29; 95% CI: 1.38–3.77). Systemic therapy was not associated with differences in overall survival (HR: 0.77; 95% CI: 0.54–1.10). Likewise, the following factors were associated with worse cancer-specific survival: male sex (HR for female sex versus male sex: 0.60; 95% CI: 0.41–0.88), non-receipt of postoperative radiation therapy (HR: 2.17; 95% CI: 1.27–3.70), and receipt of perioperative systemic therapy (HR: 0.67; 95% CI: 0.45–0.99). Conclusion Postoperative radiotherapy following resection of adrenocortical carcinoma is associated with better overall and cancer-specific survival..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:198 |
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| Enthalten in: |
Strahlentherapie und Onkologie - 198(2021), 1 vom: 02. Sept., Seite 73-79 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abdel-Rahman, Omar [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Adjuvant treatment |
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| Anmerkungen: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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| doi: |
10.1007/s00066-021-01838-6 |
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| funding: |
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| PPN (Katalog-ID): |
OLC2077800038 |
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| 520 | |a Objective To assess the impact of postoperative radiotherapy on the outcomes of resected adrenocortical carcinoma in a real-world setting. Methods The Surveillance, Epidemiology, and End Results Research Plus database was accessed, and patients with resected non-metastatic adrenocortical carcinoma diagnosed 2010–2015 were reviewed. Kaplan–Meier estimates and log-rank testing were used to examine the impact of postoperative radiotherapy on overall and cancer-specific survival. Multivariable Cox regression analysis was used to explore factors associated with overall and cancer-specific survival. Results A total of 294 patients were included in the final analysis, including 60 patients (20.4%) who received postoperative radiotherapy. Using Kaplan–Meier estimates, individuals who received postoperative radiotherapy have better overall survival (P = 0.002). Multivariable cox regression analysis showed that the following factors were associated with worse overall survival: older age (HR: 1.01; 95% CI: 1.00–1.03), male sex (HR for female sex versus male sex: 0.61; 95% CI: 0.43–0.85), and non-receipt of postoperative radiation therapy (HR: 2.29; 95% CI: 1.38–3.77). Systemic therapy was not associated with differences in overall survival (HR: 0.77; 95% CI: 0.54–1.10). Likewise, the following factors were associated with worse cancer-specific survival: male sex (HR for female sex versus male sex: 0.60; 95% CI: 0.41–0.88), non-receipt of postoperative radiation therapy (HR: 2.17; 95% CI: 1.27–3.70), and receipt of perioperative systemic therapy (HR: 0.67; 95% CI: 0.45–0.99). Conclusion Postoperative radiotherapy following resection of adrenocortical carcinoma is associated with better overall and cancer-specific survival. | ||
| 650 | 4 | |a Adrenal tumors | |
| 650 | 4 | |a Radiation therapy | |
| 650 | 4 | |a Resection | |
| 650 | 4 | |a Surgery | |
| 650 | 4 | |a Adjuvant treatment | |
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