Systemic coagulation is activated in patients with meningioma and glioblastoma
Purpose Up to 30% of patients with glioblastoma (GBM) develop venous thromboembolism (VTE) over the course of the disease. Although not as high, the risk for VTE is also increased in patients with meningioma. Direct measurement of peak thrombin generation (TG) allows quantitative assessment of systemic coagulation activation in patients with GBM and meningioma. Our aim was to determine the extent of systemic coagulation activation induced by brain tumors, to measure the shift between pre- and post-operative peak TG in patients with GBM, and to assess the relationship between pre-surgical peak TG and pre-operative brain tumor volume on imaging. Methods Pre- and post-surgical plasma samples were obtained from successive patients with GBM and once from patients with meningioma and healthy age- and sex-matched blood donor controls. TG was measured using the calibrated automated thrombogram (CAT) assay, and tumor volumes were measured in pre-surgical MRI scans. Results Pre-surgical peak TG was higher in patients with GBM than in controls (288.6 ± 54.1 nM vs 187.1 ± 41.7 nM, respectively, P < 0.001), and, in the nine patients with GBM and paired data available, peak TG was significantly reduced after surgery (323 ± 38 nM vs 265 ± 52 nM, respectively, P = 0.007). Similarly, subjects with meningioma demonstrated higher peak TG compared to controls (242.2 ± 54.9 nM vs 177.7 ± 57.0 nM, respectively, P < 0.001). There was no association between peak TG and pre-operative tumor volume or overall survival. Conclusion Our results indicate that systemic coagulation activation occurs with both meningioma and GBM, but to a greater degree in the latter. Preoperative peak TG did not correlate with tumor volume, but removal of GBM caused a significant decrease in coagulation activation..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
|---|---|
| Enthalten in: |
Journal of neuro-oncology - 155(2021), 2 vom: 15. Okt., Seite 173-180 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yerrabothala, Swaroopa [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Brain tumors |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
|---|
| doi: |
10.1007/s11060-021-03865-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2077411171 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2077411171 | ||
| 003 | DE-627 | ||
| 005 | 20230518081557.0 | ||
| 007 | tu | ||
| 008 | 221220s2021 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11060-021-03865-w |2 doi | |
| 035 | |a (DE-627)OLC2077411171 | ||
| 035 | |a (DE-He213)s11060-021-03865-w-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Yerrabothala, Swaroopa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Systemic coagulation is activated in patients with meningioma and glioblastoma |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 | ||
| 520 | |a Purpose Up to 30% of patients with glioblastoma (GBM) develop venous thromboembolism (VTE) over the course of the disease. Although not as high, the risk for VTE is also increased in patients with meningioma. Direct measurement of peak thrombin generation (TG) allows quantitative assessment of systemic coagulation activation in patients with GBM and meningioma. Our aim was to determine the extent of systemic coagulation activation induced by brain tumors, to measure the shift between pre- and post-operative peak TG in patients with GBM, and to assess the relationship between pre-surgical peak TG and pre-operative brain tumor volume on imaging. Methods Pre- and post-surgical plasma samples were obtained from successive patients with GBM and once from patients with meningioma and healthy age- and sex-matched blood donor controls. TG was measured using the calibrated automated thrombogram (CAT) assay, and tumor volumes were measured in pre-surgical MRI scans. Results Pre-surgical peak TG was higher in patients with GBM than in controls (288.6 ± 54.1 nM vs 187.1 ± 41.7 nM, respectively, P < 0.001), and, in the nine patients with GBM and paired data available, peak TG was significantly reduced after surgery (323 ± 38 nM vs 265 ± 52 nM, respectively, P = 0.007). Similarly, subjects with meningioma demonstrated higher peak TG compared to controls (242.2 ± 54.9 nM vs 177.7 ± 57.0 nM, respectively, P < 0.001). There was no association between peak TG and pre-operative tumor volume or overall survival. Conclusion Our results indicate that systemic coagulation activation occurs with both meningioma and GBM, but to a greater degree in the latter. Preoperative peak TG did not correlate with tumor volume, but removal of GBM caused a significant decrease in coagulation activation. | ||
| 650 | 4 | |a Coagulation activation | |
| 650 | 4 | |a Thrombin generation (TG) | |
| 650 | 4 | |a Glioblastoma multiforme (GBM) | |
| 650 | 4 | |a Brain tumors | |
| 650 | 4 | |a Meningioma | |
| 700 | 1 | |a Gourley, Brett L. |4 aut | |
| 700 | 1 | |a Ford, James C. |4 aut | |
| 700 | 1 | |a Ahmed, Syed Rakin |4 aut | |
| 700 | 1 | |a Guerin, Stephen J. |4 aut | |
| 700 | 1 | |a Porter, Marc |4 aut | |
| 700 | 1 | |a Wishart, Heather A. |4 aut | |
| 700 | 1 | |a Ernstoff, Marc S. |4 aut | |
| 700 | 1 | |a Fadul, Camilo E. |4 aut | |
| 700 | 1 | |a Ornstein, Deborah L. |0 (orcid)0000-0001-8011-1437 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Springer US, 1983 |g 155(2021), 2 vom: 15. Okt., Seite 173-180 |w (DE-627)167915800 |w (DE-600)604875-4 |w (DE-576)015902951 |x 0167-594X |7 nnns |
| 773 | 1 | 8 | |g volume:155 |g year:2021 |g number:2 |g day:15 |g month:10 |g pages:173-180 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s11060-021-03865-w |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 951 | |a AR | ||
| 952 | |d 155 |j 2021 |e 2 |b 15 |c 10 |h 173-180 | ||