Comparison of Clinical Features and Outcome of Dengue Fever and Multisystem Inflammatory Syndrome in Children Associated With COVID-19 (MIS-C)
Objective To identify clinical and laboratory features that differentiate dengue fever patients from MIS-C patients and determine their outcomes. Methods This comparative cross-sectional study was done at a tertiary care teaching institute. We enrolled all hospitalized children aged 1 month–18 years and diagnosed with either MIS-C and/or dengue fever according to WHO criteria between June and December, 2020. Clinical and laboratory features and outcomes were recorded on a structured proforma. Results During the study period 34 cases of MIS-C and 83 cases of Dengue fever were enrolled. Mean age of MIS-C cases (male, 86.3%) was 7.89 (4.61) years. MIS-C with shock was seen in 15 cases (44%), MIS-C without shock in 17 cases (50%) and Kawasaki disease-like presentation in 2 cases (6%). Patients of MIS-C were younger as compared to dengue fever (P=0.002). Abdominal pain and erythematous rash were more common in dengue fever. Of the inflammatory markers, mean C reactive protein was higher in MIS-C patients [100.2 (85.1) vs 16.9 (29.3) mg/dL] (P<0.001). In contrast, serum ferritin levels were higher in dengue fever patients (P=0.03). Mean hospital stay (patient days) was longer in MIS- C compared to dengue fever (8.6 vs 6.5 days; P=0.014). Conclusions Clinical and laboratory features can give important clues to differentiate dengue fever and MIS-C and help initiate specific treatment..
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Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Indian pediatrics - 58(2021), 10 vom: 23. Juli, Seite 951-954 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dhooria, Gurdeep Singh [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
| Anmerkungen: |
© Indian Academy of Pediatrics 2021 |
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| doi: |
10.1007/s13312-021-2329-9 |
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| funding: |
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| PPN (Katalog-ID): |
OLC2077296798 |
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| 520 | |a Objective To identify clinical and laboratory features that differentiate dengue fever patients from MIS-C patients and determine their outcomes. Methods This comparative cross-sectional study was done at a tertiary care teaching institute. We enrolled all hospitalized children aged 1 month–18 years and diagnosed with either MIS-C and/or dengue fever according to WHO criteria between June and December, 2020. Clinical and laboratory features and outcomes were recorded on a structured proforma. Results During the study period 34 cases of MIS-C and 83 cases of Dengue fever were enrolled. Mean age of MIS-C cases (male, 86.3%) was 7.89 (4.61) years. MIS-C with shock was seen in 15 cases (44%), MIS-C without shock in 17 cases (50%) and Kawasaki disease-like presentation in 2 cases (6%). Patients of MIS-C were younger as compared to dengue fever (P=0.002). Abdominal pain and erythematous rash were more common in dengue fever. Of the inflammatory markers, mean C reactive protein was higher in MIS-C patients [100.2 (85.1) vs 16.9 (29.3) mg/dL] (P<0.001). In contrast, serum ferritin levels were higher in dengue fever patients (P=0.03). Mean hospital stay (patient days) was longer in MIS- C compared to dengue fever (8.6 vs 6.5 days; P=0.014). Conclusions Clinical and laboratory features can give important clues to differentiate dengue fever and MIS-C and help initiate specific treatment. | ||
| 650 | 4 | |a Diagnosis | |
| 650 | 4 | |a Evaluation | |
| 650 | 4 | |a Inflammatory markers | |
| 650 | 4 | |a Management | |
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| 700 | 1 | |a Pooni, Puneet A. |4 aut | |
| 700 | 1 | |a Bhat, Deepak |4 aut | |
| 700 | 1 | |a Bhargava, Siddharth |4 aut | |
| 700 | 1 | |a Arora, Kamal |4 aut | |
| 700 | 1 | |a Gill, Karambir |4 aut | |
| 700 | 1 | |a Goel, Nancy |4 aut | |
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