Antiproliferative effect of organoclay, poly(NCA) and their nanocomposites on HeLa cell line
Abstract In this study, the synthesis, characterization and thermal properties of poly(N-cyclohexylacrylamide) polymer/organoclay-based nanocomposites were investigated by in situ polymerization. FTIR, XRD, SEM and TGA techniques have been used in the characterization of nanomaterials and whether they are exfoliated or intercalated has been investigated. It was determined from XRD and SEM measurements that the morphology of nanocomposites was exfoliated when the clay content in the polymer matrix was kept at 3% and 5%. From thermal analysis, a positive correlation was observed between the clay ratio and thermal stability of nanomaterials. Furthermore, in vitro anticancer efficacy against HeLa cell has been studied and reported by 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide assay. According to the findings, nanocomposites have been successfully synthesized and characterized and their cytotoxic properties have been proven by in vitro study. However, the potential of these nanocomposites as a drug delivery system is needed to be validated and proved in vivo studies in further research..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
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| Enthalten in: |
Polymer bulletin - 78(2020), 12 vom: 19. Nov., Seite 7325-7335 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Çankaya, Nevin [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
-Cyclohexylacrylamide (NCA) |
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| Anmerkungen: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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| doi: |
10.1007/s00289-020-03449-0 |
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| funding: |
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| 520 | |a Abstract In this study, the synthesis, characterization and thermal properties of poly(N-cyclohexylacrylamide) polymer/organoclay-based nanocomposites were investigated by in situ polymerization. FTIR, XRD, SEM and TGA techniques have been used in the characterization of nanomaterials and whether they are exfoliated or intercalated has been investigated. It was determined from XRD and SEM measurements that the morphology of nanocomposites was exfoliated when the clay content in the polymer matrix was kept at 3% and 5%. From thermal analysis, a positive correlation was observed between the clay ratio and thermal stability of nanomaterials. Furthermore, in vitro anticancer efficacy against HeLa cell has been studied and reported by 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide assay. According to the findings, nanocomposites have been successfully synthesized and characterized and their cytotoxic properties have been proven by in vitro study. However, the potential of these nanocomposites as a drug delivery system is needed to be validated and proved in vivo studies in further research. | ||
| 650 | 4 | |a -Cyclohexylacrylamide (NCA) | |
| 650 | 4 | |a Polymer/organoclay nanocomposite | |
| 650 | 4 | |a Organoclay | |
| 650 | 4 | |a Thermal stability | |
| 650 | 4 | |a In situ polymerization | |
| 650 | 4 | |a HeLa cell line | |
| 650 | 4 | |a Antiproliferative activity | |
| 700 | 1 | |a Vurgun, Bahar |4 aut | |
| 700 | 1 | |a Yalçın, Serap |4 aut | |
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