Imaging approaches to assess the therapeutic response of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): current perspectives and future trends of an exciting field in development
Abstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a family of neoplasms with a complex spectrum of clinical behavior. Although generally more indolent than carcinomas, once they progress beyond surgical resectability, they are essentially incurable. Systemic treatment options have substantially expanded in recent years for the management of advanced disease. Imaging plays a major role in new drug development, as it is the main tool used to objectively evaluate response to novel agents. However, current standard response criteria have proven suboptimal for the assessment of the antiproliferative effect of many targeted agents, particularly in the context of slow-growing tumors such as well-differentiated NETs. The aims of this article are to discuss the advantages and limitations of conventional radiological techniques and standard response assessment criteria and to review novel imaging modalities in development as well as alternative cancer- and therapy-specific criteria to assess drug efficacy in the field of GEP-NETs..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2015 |
---|---|
Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
---|---|
Enthalten in: |
Cancer and metastasis reviews - 34(2015), 4 vom: 03. Okt., Seite 823-842 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Garcia-Carbonero, Rocio [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
BKL: | |
---|---|
Themen: |
Functional imaging |
Anmerkungen: |
© The Author(s) 2015 |
---|
doi: |
10.1007/s10555-015-9598-5 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC2066354902 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | OLC2066354902 | ||
003 | DE-627 | ||
005 | 20230503013705.0 | ||
007 | tu | ||
008 | 200819s2015 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s10555-015-9598-5 |2 doi | |
035 | |a (DE-627)OLC2066354902 | ||
035 | |a (DE-He213)s10555-015-9598-5-p | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q VZ |
084 | |a 44.00$jMedizin: Allgemeines |2 bkl | ||
100 | 1 | |a Garcia-Carbonero, Rocio |e verfasserin |4 aut | |
245 | 1 | 0 | |a Imaging approaches to assess the therapeutic response of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): current perspectives and future trends of an exciting field in development |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a © The Author(s) 2015 | ||
520 | |a Abstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a family of neoplasms with a complex spectrum of clinical behavior. Although generally more indolent than carcinomas, once they progress beyond surgical resectability, they are essentially incurable. Systemic treatment options have substantially expanded in recent years for the management of advanced disease. Imaging plays a major role in new drug development, as it is the main tool used to objectively evaluate response to novel agents. However, current standard response criteria have proven suboptimal for the assessment of the antiproliferative effect of many targeted agents, particularly in the context of slow-growing tumors such as well-differentiated NETs. The aims of this article are to discuss the advantages and limitations of conventional radiological techniques and standard response assessment criteria and to review novel imaging modalities in development as well as alternative cancer- and therapy-specific criteria to assess drug efficacy in the field of GEP-NETs. | ||
650 | 4 | |a Neuroendocrine tumors | |
650 | 4 | |a Response assessment | |
650 | 4 | |a Response criteria | |
650 | 4 | |a Radiological evaluation | |
650 | 4 | |a Functional imaging | |
700 | 1 | |a Garcia-Figueiras, Roberto |4 aut | |
700 | 1 | |a Carmona-Bayonas, Alberto |4 aut | |
700 | 1 | |a Sevilla, Isabel |4 aut | |
700 | 1 | |a Teule, Alex |4 aut | |
700 | 1 | |a Quindos, Maria |4 aut | |
700 | 1 | |a Grande, Enrique |4 aut | |
700 | 1 | |a Capdevila, Jaume |4 aut | |
700 | 1 | |a Aller, Javier |4 aut | |
700 | 1 | |a Arbizu, Javier |4 aut | |
700 | 1 | |a Jimenez-Fonseca, Paula |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Cancer and metastasis reviews |d Springer US, 1982 |g 34(2015), 4 vom: 03. Okt., Seite 823-842 |w (DE-627)167915657 |w (DE-600)604857-2 |w (DE-576)015902935 |x 0167-7659 |7 nnns |
773 | 1 | 8 | |g volume:34 |g year:2015 |g number:4 |g day:03 |g month:10 |g pages:823-842 |
856 | 4 | 1 | |u https://doi.org/10.1007/s10555-015-9598-5 |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a GBV_ILN_4012 | ||
912 | |a GBV_ILN_4219 | ||
936 | b | k | |a 44.00$jMedizin: Allgemeines |q VZ |0 106409646 |0 (DE-625)106409646 |
951 | |a AR | ||
952 | |d 34 |j 2015 |e 4 |b 03 |c 10 |h 823-842 |