Association between transforming growth factor-α polymorphism and ankylosing spondylitis: a meta-analysis update
Objectives The reported results of the relationship between genetic polymorphisms of tumor necrosis factor (TNF)-α −238, −308 locus and ankylosing spondylitis (AS) susceptibility are not always consistent. This article aims to perform a meta-analysis to collect all the relevant studies to date to further clarify the relationship between those genetic polymorphisms and AS. Methods A computer search was carried out up to September 2011 for literature pertaining to AS and TNF-α polymorphisms. Results Twenty-two articles were included, with 2,506 cases of AS and 3,023 normal controls. We searched for genotypes A allele vs. G allele, AA vs. GG + GA, and GA + AA vs. GG in a fixed/random-effects model. The effect summary odds ratios (ORs) and 95 % confidence intervals (CIs) were obtained, which shows there was no association between genetic polymorphisms and AS. As the heterogeneity was observed, in a subgroup analysis by ethnicity, the degree of risk of two genes with AS susceptibility was similar in populations of European and Asian origin. For the human leukocyte antigen (HLA)-B27+ population, results were not statistically significant. Conclusion ORs of various comparisons indicate that there is no association between TNF-α −238, −308 polymorphisms and AS susceptibility in the overall population and in the subgroup of Asian and non-Asian descent..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Modern rheumatology - 23(2012), 2 vom: 02. Juni, Seite 334-344 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Chencheng [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Ankylosing spondylitis |
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| Anmerkungen: |
© Japan College of Rheumatology 2012 |
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| doi: |
10.1007/s10165-012-0659-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2065784822 |
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| 245 | 1 | 0 | |a Association between transforming growth factor-α polymorphism and ankylosing spondylitis: a meta-analysis update |
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| 520 | |a Objectives The reported results of the relationship between genetic polymorphisms of tumor necrosis factor (TNF)-α −238, −308 locus and ankylosing spondylitis (AS) susceptibility are not always consistent. This article aims to perform a meta-analysis to collect all the relevant studies to date to further clarify the relationship between those genetic polymorphisms and AS. Methods A computer search was carried out up to September 2011 for literature pertaining to AS and TNF-α polymorphisms. Results Twenty-two articles were included, with 2,506 cases of AS and 3,023 normal controls. We searched for genotypes A allele vs. G allele, AA vs. GG + GA, and GA + AA vs. GG in a fixed/random-effects model. The effect summary odds ratios (ORs) and 95 % confidence intervals (CIs) were obtained, which shows there was no association between genetic polymorphisms and AS. As the heterogeneity was observed, in a subgroup analysis by ethnicity, the degree of risk of two genes with AS susceptibility was similar in populations of European and Asian origin. For the human leukocyte antigen (HLA)-B27+ population, results were not statistically significant. Conclusion ORs of various comparisons indicate that there is no association between TNF-α −238, −308 polymorphisms and AS susceptibility in the overall population and in the subgroup of Asian and non-Asian descent. | ||
| 650 | 4 | |a Ankylosing spondylitis | |
| 650 | 4 | |a Genetic polymorphisms | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Tumor necrosis factor-α | |
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| 700 | 1 | |a Chang, Weiwei |4 aut | |
| 700 | 1 | |a Xu, Zhiwei |4 aut | |
| 700 | 1 | |a Han, Qin |4 aut | |
| 700 | 1 | |a Shan, Xiaowei |4 aut | |
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