Influence of outdoor temperature and humidity on the methacholine challenge test
Abstract Objective of this study was to evaluate whether outdoor temperature and humidity can influence methacholine test results in outpatients living in temperate areas. 4,723 subjects (2,391 males; age: 35.1 ± 16.15; $ FEV_{1} $ = 100.36 % [relative interquartile range (IQR):92.34–108.8]) that performed methacholine tests for suspected asthma between 2000 and 2010 were considered. Outdoor minimum, mean, and maximum temperature values (°C), relative humidity (%), and dew point (Tdp), registered when performing the tests, were examined. Airways hyperresponsive patients, with $ PD_{20} $ (provocative dose to obtain a 20 % fall in FEV1) <3,200 μg were 2,889 (61.2 %) and median $ PD_{20} $ was 359 μg [IQR:160-967]. On receiving operating curve (ROC) analysis, temperature, humidity, and Tdp did not significantly predict airways hyperresponsiveness (AHR), even using a 200, 800, and 3,200 μg cutoffs to identify AHR. When subjects were subdivided into subgroups, according to different levels of temperature, humidity, and dew point, no differences in $ PD_{20} $ and prevalence were found. Only a higher number of hyperresponsive subjects was detected in smokers when they were tested in hot and humid conditions. A weak but significantly positive relationship between $ PD_{20} $ and mean, maximum, and minimum temperatures was detected in severe hyperresponsive subjects ($ PD_{20} $ < 200 μg) (r = 0.100, 0.112, 0.110, respectively; p = 0.001). The regression logistic model showed that maximum temperature was a significantly protective factor for AHR (OR:0.995, 95 % CI: 0.982–0.998; p = 0.012) especially in severe hyperresponsive subjects (OR:0.988, 95 % CI: 0.977–0.999; p = 0.035). In conclusion, weather conditions do not seem to influence $ PD_{20} $ values obtained with methacholine tests in real life. Hot and humid environments may increase the prevalence of AHR in smokers while a temperature increase may reduce the AHR risk especially in severe hyperresponsive subjects..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Aerobiologia - 29(2012), 2 vom: 01. Aug., Seite 187-200 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sposato, Bruno [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Airway hyperresponsiveness |
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| Anmerkungen: |
© Springer Science+Business Media B.V. 2012 |
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| doi: |
10.1007/s10453-012-9272-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2063434840 |
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| 520 | |a Abstract Objective of this study was to evaluate whether outdoor temperature and humidity can influence methacholine test results in outpatients living in temperate areas. 4,723 subjects (2,391 males; age: 35.1 ± 16.15; $ FEV_{1} $ = 100.36 % [relative interquartile range (IQR):92.34–108.8]) that performed methacholine tests for suspected asthma between 2000 and 2010 were considered. Outdoor minimum, mean, and maximum temperature values (°C), relative humidity (%), and dew point (Tdp), registered when performing the tests, were examined. Airways hyperresponsive patients, with $ PD_{20} $ (provocative dose to obtain a 20 % fall in FEV1) <3,200 μg were 2,889 (61.2 %) and median $ PD_{20} $ was 359 μg [IQR:160-967]. On receiving operating curve (ROC) analysis, temperature, humidity, and Tdp did not significantly predict airways hyperresponsiveness (AHR), even using a 200, 800, and 3,200 μg cutoffs to identify AHR. When subjects were subdivided into subgroups, according to different levels of temperature, humidity, and dew point, no differences in $ PD_{20} $ and prevalence were found. Only a higher number of hyperresponsive subjects was detected in smokers when they were tested in hot and humid conditions. A weak but significantly positive relationship between $ PD_{20} $ and mean, maximum, and minimum temperatures was detected in severe hyperresponsive subjects ($ PD_{20} $ < 200 μg) (r = 0.100, 0.112, 0.110, respectively; p = 0.001). The regression logistic model showed that maximum temperature was a significantly protective factor for AHR (OR:0.995, 95 % CI: 0.982–0.998; p = 0.012) especially in severe hyperresponsive subjects (OR:0.988, 95 % CI: 0.977–0.999; p = 0.035). In conclusion, weather conditions do not seem to influence $ PD_{20} $ values obtained with methacholine tests in real life. Hot and humid environments may increase the prevalence of AHR in smokers while a temperature increase may reduce the AHR risk especially in severe hyperresponsive subjects. | ||
| 650 | 4 | |a Airway hyperresponsiveness | |
| 650 | 4 | |a Temperature | |
| 650 | 4 | |a Humidity | |
| 650 | 4 | |a Methacholine test | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Environment | |
| 700 | 1 | |a Scalese, Marco |4 aut | |
| 700 | 1 | |a Pammolli, Andrea |4 aut | |
| 700 | 1 | |a Pareo, Carlo |4 aut | |
| 700 | 1 | |a Scala, Raffaele |4 aut | |
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