Surgical options in radiotherapy-failed early glottic cancer

Abstract After failure of curative radiotherapy (RT), surgery is the main therapeutic option to control recurrent laryngeal cancer. Recurrences after RT for T1–T2 tumours of the glottic larynx are often diagnosed at a more severe stage than the original disease and, thus, usually treated by radical approaches. Our aim is to investigate the feasibility of more conservative strategies for proper treatment of post-RT recurred glottic cancer. We collected and reviewed our files from 1990 to 2006, selecting 75 patients which matched the following inclusion criteria: (1) patient was originally diagnosed with early stage squamous cell carcinoma of the glottic larynx (stage I–II according to 2010 TNM), (2) patient was treated by RT with curative intent, (3) patient presented a recurrence of disease after RT which was surgically treated at our Institution. T stage at first diagnosis was T1a in 41 cases (55 %), T1b in 12 (16 %) and T2 in 22 (29 %). At clinical examination of RT-recurred lesions, we documented advanced lesions (rT3–rT4) in 29 out of 75 patients (39 %). Overall, an upstage was reported for 56 % RT-recurred cancers, while 37.3 % remained at the same stage than the original tumour and 6.7 % were downstaged. Twelve patients (16 %) underwent salvage partial laryngectomy (SPL), while 63 (84 %) received a salvage total laryngectomy (STL). Multivariate analysis showed that rTNM according to the AJCC-UICC of 2010 was the only prognostic factor for both disease-free survival (p = 0.042) and overall survival (p = 0.004). Considering the prognostic impact of rT and rN we documented a statistical significance only in terms of overall survival for both factors (p = 0.004 and p = 0.04, respectively). Although STL remains the most frequent treatment choice for failures after RT in laryngeal carcinomas, SPL represents a valid option for selected patients with limited recurrence and can deliver good oncologic and functional results if performed according to careful indications..

Medienart:	Artikel

Erscheinungsjahr:	2013
Erschienen:	2013

Enthalten in:	Zur Gesamtaufnahme - volume:271
Enthalten in:	European archives of oto-rhino-laryngology and head & neck - 271(2013), 4 vom: 13. Juni, Seite 777-785

Sprache:	Englisch

Beteiligte Personen:	Santoro, Roberto [VerfasserIn] Meccariello, Giuseppe [VerfasserIn] Mannelli, Giuditta [VerfasserIn] Bini, Belinda [VerfasserIn] Paiar, Fabiola [VerfasserIn] Gallo, Oreste [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Cancer Failure Glottic Radiotherapy Salvage Surgery

RVK:	RVK Klassifikation XA 26650

Anmerkungen:	© Springer-Verlag Berlin Heidelberg 2013

doi:	10.1007/s00405-013-2583-0

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2056350262