Interleukin-6-174 Genotype, Periodontal Disease and Adverse Pregnancy Outcomes: A Pilot Study
Abstract This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary’s Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for −174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian(P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the −174 C/C genotype and IUGR was observed (P = 0.06). The −174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of −174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Journal of clinical immunology - 28(2008), 3 vom: 08. Jan., Seite 237-243 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dashash, M. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
| Anmerkungen: |
© Springer Science+Business Media, LLC 2007 |
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| doi: |
10.1007/s10875-007-9162-3 |
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| funding: |
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| PPN (Katalog-ID): |
OLC2049630751 |
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| 520 | |a Abstract This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary’s Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for −174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian(P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the −174 C/C genotype and IUGR was observed (P = 0.06). The −174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of −174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR. | ||
| 650 | 4 | |a Periodontitis | |
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| 700 | 1 | |a Baker, P. |4 aut | |
| 700 | 1 | |a Tansinda, D. |4 aut | |
| 700 | 1 | |a Blinkhorn, F. |4 aut | |
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