Increased Serum Levels of Soluble CD30 in Patients with Common Variable Immunodeficiency and Its Clinical Implications
Abstract Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this study. Soluble CD30 (sCD30) serum levels of the subjects were measured and compared. Serum levels of sCD30 in the patients with CVID were significantly increased in comparison with controls (36.93 ± 32.38 vs 5.27 ± 1.32 U/ml, P < 0.001). The group of patients with splenomegaly and reversed ratio of CD3+CD4+ T cells/CD3+CD8+ T cells had the highest serum levels of sCD30 (66.01 ± 43.34 U/ml) in comparison with other patients (P = 0.010). High levels of sCD30 in the CVID patients with splenomegaly and the presence of lymphoma in a patient with the highest level of sCD30 may suggest a soluble form of this marker as a prognostic tool in such diseases..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2007 |
|---|---|
| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Journal of clinical immunology - 28(2007), 1 vom: 03. Okt., Seite 78-84 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rezaei, Nima [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
| Anmerkungen: |
© Springer Science+Business Media, LLC 2007 |
|---|
| doi: |
10.1007/s10875-007-9135-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2049630484 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2049630484 | ||
| 003 | DE-627 | ||
| 005 | 20230503134526.0 | ||
| 007 | tu | ||
| 008 | 200819s2007 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10875-007-9135-6 |2 doi | |
| 035 | |a (DE-627)OLC2049630484 | ||
| 035 | |a (DE-He213)s10875-007-9135-6-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 44.00 |2 bkl | ||
| 100 | 1 | |a Rezaei, Nima |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased Serum Levels of Soluble CD30 in Patients with Common Variable Immunodeficiency and Its Clinical Implications |
| 264 | 1 | |c 2007 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer Science+Business Media, LLC 2007 | ||
| 520 | |a Abstract Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this study. Soluble CD30 (sCD30) serum levels of the subjects were measured and compared. Serum levels of sCD30 in the patients with CVID were significantly increased in comparison with controls (36.93 ± 32.38 vs 5.27 ± 1.32 U/ml, P < 0.001). The group of patients with splenomegaly and reversed ratio of CD3+CD4+ T cells/CD3+CD8+ T cells had the highest serum levels of sCD30 (66.01 ± 43.34 U/ml) in comparison with other patients (P = 0.010). High levels of sCD30 in the CVID patients with splenomegaly and the presence of lymphoma in a patient with the highest level of sCD30 may suggest a soluble form of this marker as a prognostic tool in such diseases. | ||
| 650 | 4 | |a Common variable immunodeficiency | |
| 650 | 4 | |a soluble CD30 | |
| 650 | 4 | |a splenomegaly | |
| 700 | 1 | |a Haji-Molla-Hoseini, Mostafa |4 aut | |
| 700 | 1 | |a Aghamohammadi, Asghar |4 aut | |
| 700 | 1 | |a Pourfathollah, Ali Akbar |4 aut | |
| 700 | 1 | |a Moghtadaie, Mina |4 aut | |
| 700 | 1 | |a Pourpak, Zahra |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical immunology |d Springer US, 1981 |g 28(2007), 1 vom: 03. Okt., Seite 78-84 |w (DE-627)168589001 |w (DE-600)779361-3 |w (DE-576)016104072 |x 0271-9142 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2007 |g number:1 |g day:03 |g month:10 |g pages:78-84 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s10875-007-9135-6 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | b | k | |a 44.00 |q VZ |
| 951 | |a AR | ||
| 952 | |d 28 |j 2007 |e 1 |b 03 |c 10 |h 78-84 | ||