Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study
Abstract Chronic periaortitis is thought to result from an autoallergic reaction to oxidized low-density lipoprotein (OxLDL). No data exist on lipid profile and atherosclerotic biomarkers. We investigated circulating levels of OxLDL and of anti-OxLDL (aOxLDL) antibodies in patients with chronic periaortitis using the cross-sectional case–control study on 20 patients with chronic periaortitis. Patients were compared to 20 age- and sex-matched controls. aOxLDL antibodies were measured by ELISA and expressed as mean optical density values at 450 nm from duplicate measurements ($ OD_{450} $). aOxLDL antibody titers (median [interquartile range]) did not differ significantly between patients and controls (aOxLDL-IgM: 0.70 [0.24–1.08] vs. 0.54 [0.25–0.73] $ OD_{450} $; aOxLDL-IgG: 0.59 [0.38–0.75] vs. 0.41[0.33–0.63]$ OD_{450} $). Female patients had higher aOxLDL-IgM levels than male patients (1.02 [0.46–1.38] vs. 0.29 [0.22–0.84] $ OD_{450} $; P = 0.05). aOxLDL-IgM titers were lower in patients with cardiovascular disease (CVD) than in patients without CVD (0.22 [0.16–0.37] vs. 0.92 [0.70–1.30] $ OD_{450} $; P = 0.003) and correlated positively with HDL-cholesterol (r = 0.47, 95% CI 0.02–0.69; P = 0.03) and inversely with diastolic blood pressure (r = −0.46, 95% CI −0.75 to −0.01; P = 0.03) and OxLDL/apoB ratio (r = −0.41, 95% CI −0.73 to 0.04; P = 0.06). No differences or associations were found between aOxLDL-IgG titers and other variables between or within patients and/or controls. In patients OxLDL levels correlated with smoking pack-years (r = 0.58, 95% CI 0.17–0.81; P = 0.007). Data suggest a differing innate immune response to OxLDL in patients with chronic periaortitis compared to controls. Whether this response is causally related to chronic periaortitis development remains to be clarified..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Rheumatology international - 31(2009), 2 vom: 12. Dez., Seite 201-208 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Bommel, E. F. H. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Apolipoprotein B |
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| Anmerkungen: |
© Springer-Verlag 2009 |
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| doi: |
10.1007/s00296-009-1288-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC2044900394 |
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| 245 | 1 | 0 | |a Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study |
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| 520 | |a Abstract Chronic periaortitis is thought to result from an autoallergic reaction to oxidized low-density lipoprotein (OxLDL). No data exist on lipid profile and atherosclerotic biomarkers. We investigated circulating levels of OxLDL and of anti-OxLDL (aOxLDL) antibodies in patients with chronic periaortitis using the cross-sectional case–control study on 20 patients with chronic periaortitis. Patients were compared to 20 age- and sex-matched controls. aOxLDL antibodies were measured by ELISA and expressed as mean optical density values at 450 nm from duplicate measurements ($ OD_{450} $). aOxLDL antibody titers (median [interquartile range]) did not differ significantly between patients and controls (aOxLDL-IgM: 0.70 [0.24–1.08] vs. 0.54 [0.25–0.73] $ OD_{450} $; aOxLDL-IgG: 0.59 [0.38–0.75] vs. 0.41[0.33–0.63]$ OD_{450} $). Female patients had higher aOxLDL-IgM levels than male patients (1.02 [0.46–1.38] vs. 0.29 [0.22–0.84] $ OD_{450} $; P = 0.05). aOxLDL-IgM titers were lower in patients with cardiovascular disease (CVD) than in patients without CVD (0.22 [0.16–0.37] vs. 0.92 [0.70–1.30] $ OD_{450} $; P = 0.003) and correlated positively with HDL-cholesterol (r = 0.47, 95% CI 0.02–0.69; P = 0.03) and inversely with diastolic blood pressure (r = −0.46, 95% CI −0.75 to −0.01; P = 0.03) and OxLDL/apoB ratio (r = −0.41, 95% CI −0.73 to 0.04; P = 0.06). No differences or associations were found between aOxLDL-IgG titers and other variables between or within patients and/or controls. In patients OxLDL levels correlated with smoking pack-years (r = 0.58, 95% CI 0.17–0.81; P = 0.007). Data suggest a differing innate immune response to OxLDL in patients with chronic periaortitis compared to controls. Whether this response is causally related to chronic periaortitis development remains to be clarified. | ||
| 650 | 4 | |a Chronic periaortitis | |
| 650 | 4 | |a Autoantibodies | |
| 650 | 4 | |a Oxidized low-density lipoprotein | |
| 650 | 4 | |a Apolipoprotein B | |
| 650 | 4 | |a Atherosclerosis | |
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| 700 | 1 | |a van den Berg, E. A. |4 aut | |
| 700 | 1 | |a Prins, J. |4 aut | |
| 700 | 1 | |a Stalenhoef, A. F. H. |4 aut | |
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