The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2
Objective The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX). Methods Measurement of COX-1 and COX-2 activity was performed by using whole blood assay. Serum thromboxane (TXA) and plasma prostaglandin 2 (PGE2) levels were determined using a commercially available enzyme immunoassay kit. Celecoxib, etodolac, and nimesulide were also tested as controls. Since the study was intended to find a qualitative effect rather than a quantitative relationship between the drugs and the enzymes, we used higher concentrations than the therapeutic range. Results Colchicine did not have an inhibitory effect on cyclo-oxygenases. Hydroxychloroquine had a mild inhibitory effect in a relatively high concentration. As expected, celecoxib, etodolac, and nimesulide did have an inhibitory effect on the cyclo-oxygenases. Conclusions Neither colchicine nor hydroxychloroquine exert their anti-inhibitory effect through inhibition of cyclo-oxygenases..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Rheumatology international - 25(2004), 5 vom: 13. Feb., Seite 332-335 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ben-Chetrit, Eldad [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Colchicine |
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| Anmerkungen: |
© Springer-Verlag 2004 |
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| doi: |
10.1007/s00296-004-0442-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC204488772X |
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| 100 | 1 | |a Ben-Chetrit, Eldad |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2 |
| 264 | 1 | |c 2004 | |
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| 500 | |a © Springer-Verlag 2004 | ||
| 520 | |a Objective The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX). Methods Measurement of COX-1 and COX-2 activity was performed by using whole blood assay. Serum thromboxane (TXA) and plasma prostaglandin 2 (PGE2) levels were determined using a commercially available enzyme immunoassay kit. Celecoxib, etodolac, and nimesulide were also tested as controls. Since the study was intended to find a qualitative effect rather than a quantitative relationship between the drugs and the enzymes, we used higher concentrations than the therapeutic range. Results Colchicine did not have an inhibitory effect on cyclo-oxygenases. Hydroxychloroquine had a mild inhibitory effect in a relatively high concentration. As expected, celecoxib, etodolac, and nimesulide did have an inhibitory effect on the cyclo-oxygenases. Conclusions Neither colchicine nor hydroxychloroquine exert their anti-inhibitory effect through inhibition of cyclo-oxygenases. | ||
| 650 | 4 | |a Colchicine | |
| 650 | 4 | |a Cyclo-oxgenase 1 | |
| 650 | 4 | |a Cyclo-oxgenase 2 | |
| 650 | 4 | |a Hydroxychloroquine | |
| 650 | 4 | |a Prostaglandins | |
| 700 | 1 | |a Fischel, Ruth |4 aut | |
| 700 | 1 | |a Hinz, Burkhard |4 aut | |
| 700 | 1 | |a Levy, Micha |4 aut | |
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