Cranio-facial dysmorphism: experimental study in the mouse, clinical applications
Summary To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyltriazene..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1999 |
|---|---|
| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Surgical and radiologic anatomy / Englische Ausgabe - 21(1999), 1 vom: Jan., Seite 41-47 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Glineur, R. [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Anmerkungen: |
© Springer-Verlag 1999 |
|---|
| doi: |
10.1007/BF01635051 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2044470365 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2044470365 | ||
| 003 | DE-627 | ||
| 005 | 20230324205211.0 | ||
| 007 | tu | ||
| 008 | 200819s1999 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF01635051 |2 doi | |
| 035 | |a (DE-627)OLC2044470365 | ||
| 035 | |a (DE-He213)BF01635051-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Glineur, R. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cranio-facial dysmorphism: experimental study in the mouse, clinical applications |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer-Verlag 1999 | ||
| 520 | |a Summary To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyltriazene. | ||
| 700 | 1 | |a Louryan, S. |4 aut | |
| 700 | 1 | |a Lemaître, A. |4 aut | |
| 700 | 1 | |a Evrard, L. |4 aut | |
| 700 | 1 | |a Rooze, M. |4 aut | |
| 700 | 1 | |a De Vos, L. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Surgical and radiologic anatomy / Englische Ausgabe |d Springer-Verlag, 1986 |g 21(1999), 1 vom: Jan., Seite 41-47 |w (DE-627)130425087 |w (DE-600)632839-8 |w (DE-576)015925919 |x 0930-1038 |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:1999 |g number:1 |g month:01 |g pages:41-47 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/BF01635051 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_2018 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 912 | |a GBV_ILN_4277 | ||
| 912 | |a GBV_ILN_4306 | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 1999 |e 1 |c 01 |h 41-47 | ||