Enhanced Detection of Sulphur and Phospho-rous Containing Compounds in HPLC-Induc-tively Coupled Plasma Mass Spectrometry Using Chemical Resolution via Hexapole-Based Reaction with Oxygen
Abstract The sensitive detection of sulphur and phosphorous-containing compounds using HPLC-ICPMS is difficult due to the high background caused by polyatomic interferences. One potential solution to the problem of polyatomic interferences for S and P is to react the latter with oxygen in the collision hexapole to separate them from interferences eg; ($ O_{2} $ on S and NOH on P). This has the effect of moving the detection mass from 31 and 32 to 47 and 48 m/z for P and S respectively. This region is clear from interferences thereby providing an increase in the sensitivity of detection for the analytes of approximately 50–100 fold. For omeprazole, a model S containing compound, a limit of detection (LOD) of 800 pg on column was achieved, an increase of ca. 100 fold in sensitivity. Similarly in the case of ZD6126 a phosphorous-containing pro-drug, an increase in sensitivity of 50 times was observed with an LOD of 1 ng on column..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Chromatographia - 59(2004), Suppl 2 vom: Mai, Seite S165-S170 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smith, C. J. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Column liquid chromatography |
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| RVK: |
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| Anmerkungen: |
© Friedr. Vieweg&Sohn Verlagsgesellschaft mbH 2004 |
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| doi: |
10.1365/s10337-004-0185-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC2044329190 |
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| 245 | 1 | 0 | |a Enhanced Detection of Sulphur and Phospho-rous Containing Compounds in HPLC-Induc-tively Coupled Plasma Mass Spectrometry Using Chemical Resolution via Hexapole-Based Reaction with Oxygen |
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| 520 | |a Abstract The sensitive detection of sulphur and phosphorous-containing compounds using HPLC-ICPMS is difficult due to the high background caused by polyatomic interferences. One potential solution to the problem of polyatomic interferences for S and P is to react the latter with oxygen in the collision hexapole to separate them from interferences eg; ($ O_{2} $ on S and NOH on P). This has the effect of moving the detection mass from 31 and 32 to 47 and 48 m/z for P and S respectively. This region is clear from interferences thereby providing an increase in the sensitivity of detection for the analytes of approximately 50–100 fold. For omeprazole, a model S containing compound, a limit of detection (LOD) of 800 pg on column was achieved, an increase of ca. 100 fold in sensitivity. Similarly in the case of ZD6126 a phosphorous-containing pro-drug, an increase in sensitivity of 50 times was observed with an LOD of 1 ng on column. | ||
| 650 | 4 | |a Column liquid chromatography | |
| 650 | 4 | |a Inductively coupled plasma mass spectrometry | |
| 650 | 4 | |a Phosphorous-containing pro-drugs | |
| 650 | 4 | |a Sulphur-containing drugs | |
| 700 | 1 | |a Wilson, I. D. |4 aut | |
| 700 | 1 | |a Weidolf, L. |4 aut | |
| 700 | 1 | |a Abou-Shakra, F. |4 aut | |
| 700 | 1 | |a Thomsen, M. |4 aut | |
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