Protective effects of intestinal trefoil factor (ITF) on gastric mucosal epithelium through activation of extracellular signal-regulated kinase 1/2 (ERK1/2)
Abstract The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF-induced gastric epithelial repair remain unclear. In the present study, we demonstrate that ITF enhances the proliferation and migration of GES-1 gastric endothelial cells in a dose- and time-dependent manner through the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Furthermore, the ITF-mediated protection of GES-1 cells from a NS398 (nonsteroidal anti-inflammatory drug) was dependent on the ERK1/2 signaling pathway. Taken together, the results provide a mechanistic explanation for ITF-mediated protection of gastric epithelial mucosa cells, suggesting that activation of the ERK1/2 signaling pathway may provide a new therapeutic strategy for repairing gastric injury..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:404 |
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| Enthalten in: |
Molecular and cellular biochemistry - 404(2015), 1-2 vom: 17. März, Seite 263-270 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Jinfeng [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Cytoprotection |
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| RVK: |
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| Anmerkungen: |
© Springer Science+Business Media New York 2015 |
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| doi: |
10.1007/s11010-015-2386-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2043113380 |
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| 245 | 1 | 0 | |a Protective effects of intestinal trefoil factor (ITF) on gastric mucosal epithelium through activation of extracellular signal-regulated kinase 1/2 (ERK1/2) |
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| 520 | |a Abstract The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF-induced gastric epithelial repair remain unclear. In the present study, we demonstrate that ITF enhances the proliferation and migration of GES-1 gastric endothelial cells in a dose- and time-dependent manner through the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Furthermore, the ITF-mediated protection of GES-1 cells from a NS398 (nonsteroidal anti-inflammatory drug) was dependent on the ERK1/2 signaling pathway. Taken together, the results provide a mechanistic explanation for ITF-mediated protection of gastric epithelial mucosa cells, suggesting that activation of the ERK1/2 signaling pathway may provide a new therapeutic strategy for repairing gastric injury. | ||
| 650 | 4 | |a Intestinal trefoil factor | |
| 650 | 4 | |a Gastric mucosal epithelium | |
| 650 | 4 | |a Cytoprotection | |
| 650 | 4 | |a ERK1/2 signaling pathway | |
| 700 | 1 | |a Sun, Zhaorui |4 aut | |
| 700 | 1 | |a Zhang, Wei |4 aut | |
| 700 | 1 | |a Liu, Hongmei |4 aut | |
| 700 | 1 | |a Shao, Danbing |4 aut | |
| 700 | 1 | |a Ren, Yi |4 aut | |
| 700 | 1 | |a Wen, Yanfang |4 aut | |
| 700 | 1 | |a Cao, Liping |4 aut | |
| 700 | 1 | |a Wolfram, Joy |4 aut | |
| 700 | 1 | |a Yang, Zhizhou |4 aut | |
| 700 | 1 | |a Nie, Shinan |4 aut | |
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