Production, quality control of next-generation PET radioisotope iodine-124 and its thyroid imaging
Abstract In this paper, 124Te(p,n)124I nuclear reaction was used for 124I production. The 124$ TeO_{2} $/$ Al_{2} $$ O_{3} $ target was irradiated by 12.5 MeV proton at 20 μA for 3–8 h in a medical cyclotron. After irradiation, 124I was purified by dry distillation and dissolved in 0.02 M NaOH, with radioactivity 370–1480 MBq. Micro-PET/CT imaging of 124I in healthy mice showed the thyroid and stomach accumulations and kidney metabolism, which may be useful for thyroid disease diagnosis. In summary, we have produced next-generation PET radioisotope 124I routinely in sufficient and high quality..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:318 |
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| Enthalten in: |
Journal of radioanalytical and nuclear chemistry - 318(2018), 3 vom: 27. Okt., Seite 1999-2006 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Feng [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
Iodine-124 |
| Anmerkungen: |
© Akadémiai Kiadó, Budapest, Hungary 2018 |
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| doi: |
10.1007/s10967-018-6277-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2041978147 |
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| 245 | 1 | 0 | |a Production, quality control of next-generation PET radioisotope iodine-124 and its thyroid imaging |
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| 520 | |a Abstract In this paper, 124Te(p,n)124I nuclear reaction was used for 124I production. The 124$ TeO_{2} $/$ Al_{2} $$ O_{3} $ target was irradiated by 12.5 MeV proton at 20 μA for 3–8 h in a medical cyclotron. After irradiation, 124I was purified by dry distillation and dissolved in 0.02 M NaOH, with radioactivity 370–1480 MBq. Micro-PET/CT imaging of 124I in healthy mice showed the thyroid and stomach accumulations and kidney metabolism, which may be useful for thyroid disease diagnosis. In summary, we have produced next-generation PET radioisotope 124I routinely in sufficient and high quality. | ||
| 650 | 4 | |a Solid target | |
| 650 | 4 | |a Iodine-124 | |
| 650 | 4 | |a Positron emission tomography (PET) | |
| 650 | 4 | |a Thyroid imaging | |
| 700 | 1 | |a Liu, Teli |4 aut | |
| 700 | 1 | |a Li, Liqiang |4 aut | |
| 700 | 1 | |a Guo, Xiaoyi |4 aut | |
| 700 | 1 | |a Duan, Dongban |4 aut | |
| 700 | 1 | |a Liu, Zhibo |4 aut | |
| 700 | 1 | |a Zhu, Hua |4 aut | |
| 700 | 1 | |a Yang, Zhi |4 aut | |
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