Electroacupuncture Attenuates Reference Memory Impairment Associated with Astrocytic NDRG2 Suppression in APP/PS1 Transgenic Mice
Abstract Electroacupuncture (EA) has demonstrated therapeutic potential for the treatment of Alzheimer's disease (AD). A previous study reported that N-myc downstream-regulated gene 2 (NDRG2) was upregulated in the brain of patients with AD. In the present study, we investigated the effects of repeated EA administration on reference memory impairment and the role of NDRG2 in an amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mouse model. Age-matched wild-type and transgenic mice were treated with EA (once per day for 30 min) for 4 weeks (four courses of 5 days EA administration and 2 days rest) beginning at 10 months of age. At seven and ten postnatal months of age and following a 4-week EA treatment regime, mice received training in the Morris water maze (MWM) and a probe test. Brain tissue was analyzed via Western blot and double-label immunofluorescence. Beginning at 7 months of age, APP/PS1 mice began to exhibit deficits in reference memory in the MWM test, an impairment associated with upregulation of glial fibrillary acidic protein (GFAP) and NDRG2. Four weeks of EA administration significantly ameliorated cognitive impairments and suppressed GFAP and NDRG2 upregulation. In conclusion, our findings demonstrated that EA administration can alleviate reference memory deficits and suppress NDRG2 upregulation in an AD transgenic mouse model. This study provides supportive evidence for EA as an effective therapeutic intervention for AD, as well as NDRG2 as a novel target for AD treatment..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2014 |
|---|---|
| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
|---|---|
| Enthalten in: |
Molecular neurobiology - 50(2014), 2 vom: 05. Jan., Seite 305-313 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Feng [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
APP/PS1 |
|---|
| Anmerkungen: |
© Springer Science+Business Media New York 2014 |
|---|
| doi: |
10.1007/s12035-013-8609-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2037492995 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2037492995 | ||
| 003 | DE-627 | ||
| 005 | 20230402061705.0 | ||
| 007 | tu | ||
| 008 | 200819s2014 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12035-013-8609-1 |2 doi | |
| 035 | |a (DE-627)OLC2037492995 | ||
| 035 | |a (DE-He213)s12035-013-8609-1-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |a 570 |q VZ |
| 084 | |a 12 |2 ssgn | ||
| 100 | 1 | |a Wang, Feng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Electroacupuncture Attenuates Reference Memory Impairment Associated with Astrocytic NDRG2 Suppression in APP/PS1 Transgenic Mice |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer Science+Business Media New York 2014 | ||
| 520 | |a Abstract Electroacupuncture (EA) has demonstrated therapeutic potential for the treatment of Alzheimer's disease (AD). A previous study reported that N-myc downstream-regulated gene 2 (NDRG2) was upregulated in the brain of patients with AD. In the present study, we investigated the effects of repeated EA administration on reference memory impairment and the role of NDRG2 in an amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mouse model. Age-matched wild-type and transgenic mice were treated with EA (once per day for 30 min) for 4 weeks (four courses of 5 days EA administration and 2 days rest) beginning at 10 months of age. At seven and ten postnatal months of age and following a 4-week EA treatment regime, mice received training in the Morris water maze (MWM) and a probe test. Brain tissue was analyzed via Western blot and double-label immunofluorescence. Beginning at 7 months of age, APP/PS1 mice began to exhibit deficits in reference memory in the MWM test, an impairment associated with upregulation of glial fibrillary acidic protein (GFAP) and NDRG2. Four weeks of EA administration significantly ameliorated cognitive impairments and suppressed GFAP and NDRG2 upregulation. In conclusion, our findings demonstrated that EA administration can alleviate reference memory deficits and suppress NDRG2 upregulation in an AD transgenic mouse model. This study provides supportive evidence for EA as an effective therapeutic intervention for AD, as well as NDRG2 as a novel target for AD treatment. | ||
| 650 | 4 | |a APP/PS1 | |
| 650 | 4 | |a NDRG2 | |
| 650 | 4 | |a Electroacupuncture | |
| 650 | 4 | |a Astrocyte | |
| 650 | 4 | |a Reference memory impairment | |
| 700 | 1 | |a Zhong, Haixing |4 aut | |
| 700 | 1 | |a Li, Xuying |4 aut | |
| 700 | 1 | |a Peng, Ye |4 aut | |
| 700 | 1 | |a Kinden, Renee |4 aut | |
| 700 | 1 | |a Liang, Wei |4 aut | |
| 700 | 1 | |a Li, Xin |4 aut | |
| 700 | 1 | |a Shi, Ming |4 aut | |
| 700 | 1 | |a Liu, Lixin |4 aut | |
| 700 | 1 | |a Wang, Qiang |4 aut | |
| 700 | 1 | |a Xiong, Lize |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular neurobiology |d Springer US, 1987 |g 50(2014), 2 vom: 05. Jan., Seite 305-313 |w (DE-627)168166593 |w (DE-600)645020-9 |w (DE-576)022915184 |x 0893-7648 |7 nnns |
| 773 | 1 | 8 | |g volume:50 |g year:2014 |g number:2 |g day:05 |g month:01 |g pages:305-313 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s12035-013-8609-1 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4082 | ||
| 912 | |a GBV_ILN_4219 | ||
| 951 | |a AR | ||
| 952 | |d 50 |j 2014 |e 2 |b 05 |c 01 |h 305-313 | ||