Functional connectivity change of brain default mode network in breast cancer patients after chemotherapy
Introduction Complaint about attention disorders is common among breast cancer patients who have undergone chemotherapy, which may be associated with the default mode network (DMN). To validate this hypothesis, we investigated the DMN functional connectivity (FC) change and its relationship with the attention function in breast cancer patients (BC) using resting-state functional magnetic resonance imaging (rs-fMRI). Methods Twenty-two BC treated with chemotherapy and 22 healthy controls (HC) were recruited into this study. The FC between the DMN’s hubs and regions of the dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL) subsystems was respectively calculated for each participant. Results The statistical result showed significantly lower connectivity in dMPFC and MTL subsystems in the BC group. In addition, the partial correlation analysis result indicated that the low connectivity of some brain regions in MTL subsystem was correlated with attention dysfunction following BC chemotherapy. Conclusion These results suggest that the functional disconnection in MTL subsystem of the DMN may have association with attention function of BC after chemotherapy..
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Artikel |
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2016 |
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Erschienen: |
2016 |
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Zur Gesamtaufnahme - volume:58 |
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Enthalten in: |
Neuroradiology - 58(2016), 9 vom: 09. Juni, Seite 921-928 |
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Englisch |
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Beteiligte Personen: |
Miao, Hui [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
Attention deficit |
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Anmerkungen: |
© Springer-Verlag Berlin Heidelberg 2016 |
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doi: |
10.1007/s00234-016-1708-8 |
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PPN (Katalog-ID): |
OLC2035197104 |
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520 | |a Introduction Complaint about attention disorders is common among breast cancer patients who have undergone chemotherapy, which may be associated with the default mode network (DMN). To validate this hypothesis, we investigated the DMN functional connectivity (FC) change and its relationship with the attention function in breast cancer patients (BC) using resting-state functional magnetic resonance imaging (rs-fMRI). Methods Twenty-two BC treated with chemotherapy and 22 healthy controls (HC) were recruited into this study. The FC between the DMN’s hubs and regions of the dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL) subsystems was respectively calculated for each participant. Results The statistical result showed significantly lower connectivity in dMPFC and MTL subsystems in the BC group. In addition, the partial correlation analysis result indicated that the low connectivity of some brain regions in MTL subsystem was correlated with attention dysfunction following BC chemotherapy. Conclusion These results suggest that the functional disconnection in MTL subsystem of the DMN may have association with attention function of BC after chemotherapy. | ||
650 | 4 | |a Default mode network | |
650 | 4 | |a Breast cancer | |
650 | 4 | |a Cognitive impairment | |
650 | 4 | |a Chemotherapy | |
650 | 4 | |a Attention deficit | |
700 | 1 | |a Chen, Xingui |4 aut | |
700 | 1 | |a Yan, Yunwen |4 aut | |
700 | 1 | |a He, Xiaoxuan |4 aut | |
700 | 1 | |a Hu, Sheng |4 aut | |
700 | 1 | |a Kong, Jian |4 aut | |
700 | 1 | |a Wu, Meiqi |4 aut | |
700 | 1 | |a Wei, Yarui |4 aut | |
700 | 1 | |a Zhou, Yawen |4 aut | |
700 | 1 | |a Wang, Lu |4 aut | |
700 | 1 | |a Wang, Kai |4 aut | |
700 | 1 | |a Qiu, Bensheng |4 aut | |
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