Propofol versus Fentanyl for Sedation in Pediatric Bronchoscopy: A Randomized Controlled Trial
Objectives To compare propofol and fentanyl to induce conscious sedation in children undergoing flexible bronchoscopy. Study design Randomized controlled trial. Setting Pediatric Pulmonology division at a tertiary care center in Delhi, India. Participants Children aged 3–15 years who underwent flexible bronchoscopy. Intervention Children received either intravenous propofol 1 mg/kg administered as a slow bolus over 1 minute followed by 2 mg/kg/hour infusion, or intravenous Fentanyl 2 µg/kg administered as a slow bolus over one minute. Outcomes Primary outcome was time to achieve conscious sedation (Ramsay score 3). Secondary outcomes were need for adjuvant midazolam, physician satisfaction, level of cough, recovery features, and side-effects in the groups. Results 53 children (propofol 27, fentanyl 26) were enrolled in the study. The mean (SD) time taken to achieve Ramsay score 03 was lower in propofol than fentanyl [15.7 (4.4) s vs 206 (55) s, P<0.001]. Propofol arm had significantly higher physician satisfaction, less requirement of adjuvant midazolam, less coughing and faster regain of full consciousness. There was no difference in drug side-effects between the groups. Conclusion Propofol has a shorter sedation induction time, less coughing during procedure, less recovery time, and better physician satisfaction compared to fentanyl for flexible bronchoscopy in children..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Indian pediatrics - 56(2019), 12 vom: Dez., Seite 1011-1016 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gunathilaka, P. K. G. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
| Anmerkungen: |
© Indian Academy of Pediatrics 2019 |
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| doi: |
10.1007/s13312-019-1681-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2028660481 |
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| 245 | 1 | 0 | |a Propofol versus Fentanyl for Sedation in Pediatric Bronchoscopy: A Randomized Controlled Trial |
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| 520 | |a Objectives To compare propofol and fentanyl to induce conscious sedation in children undergoing flexible bronchoscopy. Study design Randomized controlled trial. Setting Pediatric Pulmonology division at a tertiary care center in Delhi, India. Participants Children aged 3–15 years who underwent flexible bronchoscopy. Intervention Children received either intravenous propofol 1 mg/kg administered as a slow bolus over 1 minute followed by 2 mg/kg/hour infusion, or intravenous Fentanyl 2 µg/kg administered as a slow bolus over one minute. Outcomes Primary outcome was time to achieve conscious sedation (Ramsay score 3). Secondary outcomes were need for adjuvant midazolam, physician satisfaction, level of cough, recovery features, and side-effects in the groups. Results 53 children (propofol 27, fentanyl 26) were enrolled in the study. The mean (SD) time taken to achieve Ramsay score 03 was lower in propofol than fentanyl [15.7 (4.4) s vs 206 (55) s, P<0.001]. Propofol arm had significantly higher physician satisfaction, less requirement of adjuvant midazolam, less coughing and faster regain of full consciousness. There was no difference in drug side-effects between the groups. Conclusion Propofol has a shorter sedation induction time, less coughing during procedure, less recovery time, and better physician satisfaction compared to fentanyl for flexible bronchoscopy in children. | ||
| 650 | 4 | |a Conscious sedation | |
| 650 | 4 | |a Endoscopy | |
| 650 | 4 | |a Ramsay score | |
| 650 | 4 | |a Visual analog scale | |
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| 700 | 1 | |a Kabra, S. K. |4 aut | |
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