Inflammatory events during food protein‐induced enterocolitis syndrome reactions
Background An increasing number of infants are diagnosed with food protein-induced enterocolitis syndrome (FPIES), a non-IgE-mediated food allergy. Until now, T-cell, food-specific mechanisms have been hypothesized. Methods Sixteen children (11M, 5F), affected by FPIES from cow's milk, wheat, fruit, rice, and others, experienced 25 acute episodes managed at our emergency department (ED) and eight FPIES reactions during oral food challenges (OFC). We compared the laboratory data in resting conditions, in the absence of infectious diseases, with data collected during the 25 acute ED episodes (blood samples drawn at 2-12 hours) and the eight positive OFCs (three samples at 2, 6, and 12 hours). The onset of symptoms was used as a reference time point. Results In basal conditions, total IgE, WBC, neutrophil and eosinophil count, CRP, and SGPT were found normal. LDH and SGOT values were high (627.81±97.88 and 45.75±10.26 UI/L, respectively). During ED reactions, LDH and SGOT increased to 794.21±247.28 (P=.028) and 51.08±16.99 UI/L (P=.14) and neutrophils count and CRP to 8.44±3.82×103/µL (P=.0009) and 3.27±5.73 mg/dL (P=.0014), respectively. During positive OFC,LDH and SGOT did not vary significantly; CRP increased from 0.14±0.18 to 2.49±3.65 mg/dL (P=.00189) and neutrophil count from 2.79±1.42 to 7.10±3.98×103/µL (P=.00096). Conclusions FPIES reactions are characterized by neutrophilia and by a time-dependent, significant increase in CRP, indicating that inflammatory mechanisms are in place. This suggests new directions for research on FPIES pathogenesis..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Pediatric allergy and immunology - 28(2017), 5, Seite 464-470 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pecora, Valentina [VerfasserIn] |
|---|
| Links: |
|---|
| doi: |
10.1111/pai.12723 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1996299212 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1996299212 | ||
| 003 | DE-627 | ||
| 005 | 20230715065242.0 | ||
| 007 | tu | ||
| 008 | 170901s2017 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1111/pai.12723 |2 doi | |
| 028 | 5 | 2 | |a PQ20170901 |
| 035 | |a (DE-627)OLC1996299212 | ||
| 035 | |a (DE-599)GBVOLC1996299212 | ||
| 035 | |a (PRQ)p973-92878dbaa36fc1033889c91f0bdbf64eeb645b445cb1414c23828e0b34dbb7540 | ||
| 035 | |a (KEY)0189418820170000028000500464inflammatoryeventsduringfoodproteininducedenteroco | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 100 | 1 | |a Pecora, Valentina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Inflammatory events during food protein‐induced enterocolitis syndrome reactions |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Background An increasing number of infants are diagnosed with food protein-induced enterocolitis syndrome (FPIES), a non-IgE-mediated food allergy. Until now, T-cell, food-specific mechanisms have been hypothesized. Methods Sixteen children (11M, 5F), affected by FPIES from cow's milk, wheat, fruit, rice, and others, experienced 25 acute episodes managed at our emergency department (ED) and eight FPIES reactions during oral food challenges (OFC). We compared the laboratory data in resting conditions, in the absence of infectious diseases, with data collected during the 25 acute ED episodes (blood samples drawn at 2-12 hours) and the eight positive OFCs (three samples at 2, 6, and 12 hours). The onset of symptoms was used as a reference time point. Results In basal conditions, total IgE, WBC, neutrophil and eosinophil count, CRP, and SGPT were found normal. LDH and SGOT values were high (627.81±97.88 and 45.75±10.26 UI/L, respectively). During ED reactions, LDH and SGOT increased to 794.21±247.28 (P=.028) and 51.08±16.99 UI/L (P=.14) and neutrophils count and CRP to 8.44±3.82×103/µL (P=.0009) and 3.27±5.73 mg/dL (P=.0014), respectively. During positive OFC,LDH and SGOT did not vary significantly; CRP increased from 0.14±0.18 to 2.49±3.65 mg/dL (P=.00189) and neutrophil count from 2.79±1.42 to 7.10±3.98×103/µL (P=.00096). Conclusions FPIES reactions are characterized by neutrophilia and by a time-dependent, significant increase in CRP, indicating that inflammatory mechanisms are in place. This suggests new directions for research on FPIES pathogenesis. | ||
| 540 | |a Nutzungsrecht: © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. | ||
| 650 | 4 | |a C‐reactive protein | |
| 650 | 4 | |a food protein‐induced enterocolitis syndrome | |
| 650 | 4 | |a T‐cell food‐specific mechanisms | |
| 650 | 4 | |a inflammatory mechanisms | |
| 650 | 4 | |a Rice | |
| 650 | 4 | |a Food hypersensitivity | |
| 650 | 4 | |a Milk | |
| 650 | 4 | |a Food | |
| 650 | 4 | |a Leukocytes (neutrophilic) | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Pathogenesis | |
| 650 | 4 | |a Enterocolitis | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Time dependence | |
| 650 | 4 | |a Cow's milk | |
| 650 | 4 | |a Infectious diseases | |
| 650 | 4 | |a Neutrophils | |
| 650 | 4 | |a Emergency management | |
| 650 | 4 | |a Immunoglobulin E | |
| 650 | 4 | |a Lymphocytes T | |
| 650 | 4 | |a Wheat | |
| 650 | 4 | |a Neutrophilia | |
| 650 | 4 | |a Rodents | |
| 650 | 4 | |a Infants | |
| 650 | 4 | |a Emergency medical services | |
| 650 | 4 | |a Food allergies | |
| 700 | 1 | |a Prencipe, Giusi |4 oth | |
| 700 | 1 | |a Valluzzi, Rocco |4 oth | |
| 700 | 1 | |a Dahdah, Lamia |4 oth | |
| 700 | 1 | |a Insalaco, Antonella |4 oth | |
| 700 | 1 | |a Cianferoni, Antonella |4 oth | |
| 700 | 1 | |a De Benedetti, Fabrizio |4 oth | |
| 700 | 1 | |a Fiocchi, Alessandro |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric allergy and immunology |d Oxford : Wiley-Blackwell, 1990 |g 28(2017), 5, Seite 464-470 |w (DE-627)170435997 |w (DE-600)1057059-7 |w (DE-576)025088246 |x 0905-6157 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2017 |g number:5 |g pages:464-470 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1111/pai.12723 |3 Volltext |
| 856 | 4 | 2 | |u http://onlinelibrary.wiley.com/doi/10.1111/pai.12723/abstract |
| 856 | 4 | 2 | |u https://search.proquest.com/docview/1925083723 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4305 | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2017 |e 5 |h 464-470 | ||