Hunting for a needle in a haystack: investigating inherited diseases of sheep
Congenital anomalies could be due to a genetic disease but may also be caused either by teratogens, such as viruses and plant toxins, or be secondary to nutritional deficiencies during gestation (Dittmer and Thompson 2015). [...]veterinarians called to investigate either isolated cases or clusters of congenital anomalies should take care not to suggest a genetic basis without sufficient evidence. Samples should be collected to obtain an accurate diagnosis and if a genetic cause is suspected whole blood, liver, hair bulb or ear notch samples from affected lambs, normal siblings, dams and sires should be collected for future genetic analysis. [...]many genetic diseases cause significant welfare compromise, in which case breeding from heterozygous animals necessarily must be discouraged. [...]breeding strategies should ideally be designed around retaining genetic diversity but preventing the production of affected animals. What you need to know Not all congenital anomalies are due to genetic disease; consider also teratogenic and nutritional causes When investigating genetic diseases collect samples for DNA analysis not just from as many affected animals as possible, but also from normal siblings, dams and sires Making an accurate diagnosis is crucial to determining any disease causing mutation in downstream molecular genetic analysis Despite the many technological advances that have been made in molecular genetics, in order to make the most of these molecular genetic techniques, the foundation of any analyses are still the vital tools of the trade for any veterinarian - the physical examination and an accurate diagnosis..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:181 |
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| Enthalten in: |
The veterinary record - 181(2017), 7, Seite 164 |
| Sprache: |
Englisch |
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| BKL: | |
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| Themen: |
Animals |
| doi: |
10.1136/vr.j3748 |
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| 520 | |a Congenital anomalies could be due to a genetic disease but may also be caused either by teratogens, such as viruses and plant toxins, or be secondary to nutritional deficiencies during gestation (Dittmer and Thompson 2015). [...]veterinarians called to investigate either isolated cases or clusters of congenital anomalies should take care not to suggest a genetic basis without sufficient evidence. Samples should be collected to obtain an accurate diagnosis and if a genetic cause is suspected whole blood, liver, hair bulb or ear notch samples from affected lambs, normal siblings, dams and sires should be collected for future genetic analysis. [...]many genetic diseases cause significant welfare compromise, in which case breeding from heterozygous animals necessarily must be discouraged. [...]breeding strategies should ideally be designed around retaining genetic diversity but preventing the production of affected animals. What you need to know Not all congenital anomalies are due to genetic disease; consider also teratogenic and nutritional causes When investigating genetic diseases collect samples for DNA analysis not just from as many affected animals as possible, but also from normal siblings, dams and sires Making an accurate diagnosis is crucial to determining any disease causing mutation in downstream molecular genetic analysis Despite the many technological advances that have been made in molecular genetics, in order to make the most of these molecular genetic techniques, the foundation of any analyses are still the vital tools of the trade for any veterinarian - the physical examination and an accurate diagnosis. | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Veterinary medicine | |
| 650 | 4 | |a Epidemics | |
| 650 | 4 | |a Disease | |
| 650 | 4 | |a Congenital diseases | |
| 650 | 4 | |a Viruses | |
| 650 | 4 | |a Veterinarians | |
| 650 | 4 | |a Genetic diversity | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a Genetic disorders | |
| 650 | 4 | |a Defects | |
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