Variation in the [Beta]-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality
There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 114(2017), 20, Seite 5300 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Eiluned Pearce [VerfasserIn] |
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| 245 | 1 | 0 | |a Variation in the [Beta]-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality |
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| 520 | |a There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles. | ||
| 650 | 4 | |a Fitness | |
| 650 | 4 | |a Social organization | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Transcription | |
| 650 | 4 | |a Health | |
| 650 | 4 | |a Longevity | |
| 650 | 4 | |a Endorphins | |
| 650 | 4 | |a Serotonin | |
| 650 | 4 | |a Oxytocin | |
| 650 | 4 | |a Social interactions | |
| 650 | 4 | |a Friendship | |
| 650 | 4 | |a Social networks | |
| 650 | 4 | |a Testosterone | |
| 650 | 4 | |a Genes | |
| 650 | 4 | |a Dopamine | |
| 650 | 4 | |a Vasopressin | |
| 650 | 4 | |a Complexity | |
| 650 | 4 | |a Single-nucleotide polymorphism | |
| 650 | 4 | |a Social behavior | |
| 650 | 4 | |a Networks | |
| 650 | 4 | |a Failure | |
| 650 | 4 | |a Neuropeptides | |
| 700 | 0 | |a Rafael Wlodarski |4 oth | |
| 700 | 0 | |a Anna Machin |4 oth | |
| 700 | 0 | |a Robin I M Dunbar |4 oth | |
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| 773 | 1 | 8 | |g volume:114 |g year:2017 |g number:20 |g pages:5300 |
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