Mechanism of signal propagation in Physarum polycephalum
Complex behaviors are typically associated with animals, but the capacity to integrate information and function as a coordinated individual is also a ubiquitous but poorly understood feature of organisms such as slime molds and fungi. Plasmodial slime molds grow as networks and use flexible, undifferentiated body plans to forage for food. How an individual communicates across its network remains a puzzle, but Physarum polycephalum has emerged as a novel model used to explore emergent dynamics. Within P. polycephalum, cytoplasm is shuttled in a peristaltic wave driven by cross-sectional contractions of tubes. We first track P. polycephalum's response to a localized nutrient stimulus and observe a front of increased contraction. The front propagates with a velocity comparable to the flow-driven dispersion of particles. We build a mathematical model based on these data and in the aggregate experiments and model identify the mechanism of signal propagation across a body: The nutrient stimulus triggers the release of a signaling molecule. The molecule is advected by fluid flows but simultaneously hijacks flow generation by causing local increases in contraction amplitude as it travels. The molecule is initiating a feedback loop to enable its own movement. This mechanism explains previously puzzling phenomena, including the adaptation of the peristaltic wave to organism size and P. polycephalum's ability to find the shortest route between food sources. A simple feedback seems to give rise to P. polycephalum's complex behaviors, and the same mechanism is likely to function in the thousands of additional species with similar behaviors..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
|---|---|
| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 114(2017), 20, Seite 5136 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Karen Alim [VerfasserIn] |
|---|
| Links: |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
OLC1995553956 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1995553956 | ||
| 003 | DE-627 | ||
| 005 | 20230715062536.0 | ||
| 007 | tu | ||
| 008 | 170721s2017 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a PQ20170721 |
| 035 | |a (DE-627)OLC1995553956 | ||
| 035 | |a (DE-599)GBVOLC1995553956 | ||
| 035 | |a (PRQ)p939-76fdb4246ece3fcb95c70113fb5ec062233325f9bfea257a0b336e5d07cfa21c0 | ||
| 035 | |a (KEY)0583363920170000114002005136mechanismofsignalpropagationinphysarumpolycephalum | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 500 |q DE-101 |
| 082 | 0 | 4 | |a 570 |q AVZ |
| 084 | |a LING |2 fid | ||
| 084 | |a BIODIV |2 fid | ||
| 100 | 0 | |a Karen Alim |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mechanism of signal propagation in Physarum polycephalum |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Complex behaviors are typically associated with animals, but the capacity to integrate information and function as a coordinated individual is also a ubiquitous but poorly understood feature of organisms such as slime molds and fungi. Plasmodial slime molds grow as networks and use flexible, undifferentiated body plans to forage for food. How an individual communicates across its network remains a puzzle, but Physarum polycephalum has emerged as a novel model used to explore emergent dynamics. Within P. polycephalum, cytoplasm is shuttled in a peristaltic wave driven by cross-sectional contractions of tubes. We first track P. polycephalum's response to a localized nutrient stimulus and observe a front of increased contraction. The front propagates with a velocity comparable to the flow-driven dispersion of particles. We build a mathematical model based on these data and in the aggregate experiments and model identify the mechanism of signal propagation across a body: The nutrient stimulus triggers the release of a signaling molecule. The molecule is advected by fluid flows but simultaneously hijacks flow generation by causing local increases in contraction amplitude as it travels. The molecule is initiating a feedback loop to enable its own movement. This mechanism explains previously puzzling phenomena, including the adaptation of the peristaltic wave to organism size and P. polycephalum's ability to find the shortest route between food sources. A simple feedback seems to give rise to P. polycephalum's complex behaviors, and the same mechanism is likely to function in the thousands of additional species with similar behaviors. | ||
| 650 | 4 | |a Flow | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Food | |
| 650 | 4 | |a Contraction | |
| 650 | 4 | |a Molds | |
| 650 | 4 | |a Nutrients | |
| 650 | 4 | |a Particulates | |
| 650 | 4 | |a Molecules | |
| 650 | 4 | |a Tubes | |
| 650 | 4 | |a Forages | |
| 650 | 4 | |a Slime | |
| 650 | 4 | |a Information processing | |
| 650 | 4 | |a Cytoplasm | |
| 650 | 4 | |a Food sources | |
| 650 | 4 | |a Networks | |
| 650 | 4 | |a Adaptation | |
| 650 | 4 | |a Feedback | |
| 650 | 4 | |a Dispersion (wave) | |
| 650 | 4 | |a Nutrient release | |
| 650 | 4 | |a Cross sections | |
| 650 | 4 | |a Mathematical models | |
| 650 | 4 | |a Fungi | |
| 650 | 4 | |a Velocity | |
| 650 | 4 | |a Movement | |
| 650 | 4 | |a Dynamics | |
| 650 | 4 | |a Tracking | |
| 650 | 4 | |a Building components | |
| 650 | 4 | |a Mathematical analysis | |
| 650 | 4 | |a Organisms | |
| 650 | 4 | |a Slime molds | |
| 650 | 4 | |a Propagation | |
| 650 | 4 | |a Dispersion | |
| 700 | 0 | |a Natalie Andrew |4 oth | |
| 700 | 0 | |a Anne Pringle |4 oth | |
| 700 | 0 | |a Michael P Brenner |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : NAS, 1877 |g 114(2017), 20, Seite 5136 |w (DE-627)129505269 |w (DE-600)209104-5 |w (DE-576)014909189 |x 0027-8424 |7 nnns |
| 773 | 1 | 8 | |g volume:114 |g year:2017 |g number:20 |g pages:5136 |
| 856 | 4 | 2 | |u https://search.proquest.com/docview/1905687280 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a FID-LING | ||
| 912 | |a FID-BIODIV | ||
| 912 | |a SSG-OLC-PHY | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-MAT | ||
| 912 | |a SSG-OLC-FOR | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-MAT | ||
| 912 | |a SSG-OPC-FOR | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_59 | ||
| 951 | |a AR | ||
| 952 | |d 114 |j 2017 |e 20 |h 5136 | ||