Vitamin A supplementation redirects the flow of retinyl esters from peripheral to central organs of neonatal rats raised under vitamin A-marginal conditions.(Original Research Communications)(Report)(Author abstract)
Background: Vitamin A (VA; retinol) supplementation is used to reduce child mortality in countries with high rates of malnutrition. Existing research suggests that neonates (<1 mo old) may have a limited capacity to store VA in organs other than the liver; however, knowledge about VA distribution and kinetics in individual, nonhepatic organs is limited. Objective: We examined retinol uptake and turnover in nonhepatic organs, including skin, brain, and adipose tissue, in neonatal rats without and after VA supplementation. Design: Sprague-Dawley neonatal rats (n = 104) were nursed by mothers fed a VA-marginal diet (0.35 mg retinol/kg diet) and treated on postnatal day 4 with an oral dose of either VA (6 [micro]g retinyl palmitate/g body weight) or canola oil (control), both containing 1.8 [micro]Ci of [[sup.3]H]retinol. Subsequently, pups (n = 4 x [group.sup.-1] x [time.sup.-1]) were killed at 13 different times from 30 min to 24 d after dosing. The fractional and absolute transfer of chylomicron retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and total retinol were estimated in WinSAAM software. Results: VA supplementation redirected the flow of CM-REs from peripheral to central organs and accumulated mainly in the liver. The RBP-ROH released from the liver was acquired mainly by the peripheral tissues but not retained efficiently, causing repeated recycling of retinol between plasma and tissues (541 compared with 5 times in the supplemented group and control group, respectively) and its rapid turnover in all organs, except the brain and white adipose tissue. Retinol stores in the liver lasted for ~2 wk before being gradually transferred to other organs. Conclusions: VA supplementation administered in a single high dose during the first month after birth is readily acquired but not retained efficiently in peripheral tissues of neonatal rats, suggesting that a more frequent, lower-dose supplementation may be necessary to maintain steady VA concentrations in rapidly developing neonatal tissues. Am J Clin Nutr 2017;105:1110-21. Keywords: chylomicron, extrahepatic, growth and development, mathematical modeling, neonate, retinyl esters, vitamin A deficiency, vitamin A metabolism, vitamin A supplementation doi: 10.3945/ajcn.116.149039.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:105 |
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| Enthalten in: |
The American journal of clinical nutrition - 105(2017), 5, Seite 1110 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Green, Michael H [VerfasserIn] |
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| RVK: |
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| doi: |
10.3945/ajcn.116.149039 |
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| 245 | 1 | 0 | |a Vitamin A supplementation redirects the flow of retinyl esters from peripheral to central organs of neonatal rats raised under vitamin A-marginal conditions.(Original Research Communications)(Report)(Author abstract) |
| 264 | 1 | |c 2017 | |
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| 520 | |a Background: Vitamin A (VA; retinol) supplementation is used to reduce child mortality in countries with high rates of malnutrition. Existing research suggests that neonates (<1 mo old) may have a limited capacity to store VA in organs other than the liver; however, knowledge about VA distribution and kinetics in individual, nonhepatic organs is limited. Objective: We examined retinol uptake and turnover in nonhepatic organs, including skin, brain, and adipose tissue, in neonatal rats without and after VA supplementation. Design: Sprague-Dawley neonatal rats (n = 104) were nursed by mothers fed a VA-marginal diet (0.35 mg retinol/kg diet) and treated on postnatal day 4 with an oral dose of either VA (6 [micro]g retinyl palmitate/g body weight) or canola oil (control), both containing 1.8 [micro]Ci of [[sup.3]H]retinol. Subsequently, pups (n = 4 x [group.sup.-1] x [time.sup.-1]) were killed at 13 different times from 30 min to 24 d after dosing. The fractional and absolute transfer of chylomicron retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and total retinol were estimated in WinSAAM software. Results: VA supplementation redirected the flow of CM-REs from peripheral to central organs and accumulated mainly in the liver. The RBP-ROH released from the liver was acquired mainly by the peripheral tissues but not retained efficiently, causing repeated recycling of retinol between plasma and tissues (541 compared with 5 times in the supplemented group and control group, respectively) and its rapid turnover in all organs, except the brain and white adipose tissue. Retinol stores in the liver lasted for ~2 wk before being gradually transferred to other organs. Conclusions: VA supplementation administered in a single high dose during the first month after birth is readily acquired but not retained efficiently in peripheral tissues of neonatal rats, suggesting that a more frequent, lower-dose supplementation may be necessary to maintain steady VA concentrations in rapidly developing neonatal tissues. Am J Clin Nutr 2017;105:1110-21. Keywords: chylomicron, extrahepatic, growth and development, mathematical modeling, neonate, retinyl esters, vitamin A deficiency, vitamin A metabolism, vitamin A supplementation doi: 10.3945/ajcn.116.149039 | ||
| 540 | |a Nutzungsrecht: © COPYRIGHT 2017 American Society for Clinical Nutrition, Inc. | ||
| 650 | 4 | |a Health aspects | |
| 650 | 4 | |a Medical research | |
| 650 | 4 | |a Vitamin A | |
| 650 | 4 | |a Medicine, Experimental | |
| 650 | 4 | |a Vitamin metabolism | |
| 650 | 4 | |a Research | |
| 650 | 4 | |a Biological control systems | |
| 650 | 4 | |a Retinol-binding protein | |
| 650 | 4 | |a Tissues | |
| 650 | 4 | |a Newborn babies | |
| 650 | 4 | |a Chemical compounds | |
| 650 | 4 | |a Supplementation | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Malnutrition | |
| 650 | 4 | |a Body weight | |
| 650 | 4 | |a Design for recycling | |
| 650 | 4 | |a Stores | |
| 650 | 4 | |a Rodents | |
| 650 | 4 | |a Canola oil | |
| 650 | 4 | |a Skin | |
| 650 | 4 | |a Adipose tissues | |
| 650 | 4 | |a Brain | |
| 650 | 4 | |a Fats and oils | |
| 650 | 4 | |a Esters | |
| 650 | 4 | |a Organs | |
| 650 | 4 | |a Kinetics | |
| 650 | 4 | |a Dietary supplements | |
| 650 | 4 | |a Palmitic acid | |
| 650 | 4 | |a Liver | |
| 650 | 4 | |a Adipose tissue | |
| 650 | 4 | |a Skin (anatomy) | |
| 650 | 4 | |a Neonates | |
| 700 | 1 | |a Hodges, Joanna K |4 oth | |
| 700 | 1 | |a Tan, Libo |4 oth | |
| 700 | 1 | |a Ross, A. Catharine |4 oth | |
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| 773 | 1 | 8 | |g volume:105 |g year:2017 |g number:5 |g pages:1110 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.3945/ajcn.116.149039 |3 Volltext |
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