Clearance of Tritrichomonas foetus in experimentally infected heifers protected with vaccines based on killed-T. foetus with different adjuvants
Tritrichomonas foetusis a flagellated protozoan that causes a sexually transmitted disease in cattle. Trichomonosis is characterized by early abortions, subfertility and a significant decrease in productivity. Vaccine preparations containing wholeT. foetuscan reduce the time of residence of the pathogen in the host cervix after experimental infection. Here,T. foetusvaccines prepared with different adjuvants were tested, in parallel with a commercial vaccine, for their efficacy to clear the infection. The median time for clearance of infection was 69days in non-immunized animals, 55days in animals treated with aluminum hydroxide, 41days with oil-in-water or saponin based vaccines or with a commercial vaccine and 27days in animals treated with saponin plus aluminum hydroxide. A slight increase in the risk ofT. foetusclearance from the genital tract was found with the saponin based vaccine (hazard ratio, 2.52; 95% confidence interval, 1.03-6.17) or the commercial vaccine (hazard ratio, 2.61; 95% confidence interval, 1.07-6.38). A significant increase in the risk ofT. foetusclearance was found with the combination of saponin plus aluminum hydroxide based vaccine (hazard ratio, 5.12; 95% confidence interval, 2.04-12.83)..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Vaccine - 35(2017), 9, Seite 1341-1346 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fuchs, Lumila I [VerfasserIn] |
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| Links: |
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| Themen: |
Aluminum |
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| doi: |
10.1016/j.vaccine.2016.12.030 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC1992914427 |
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| 245 | 1 | 0 | |a Clearance of Tritrichomonas foetus in experimentally infected heifers protected with vaccines based on killed-T. foetus with different adjuvants |
| 264 | 1 | |c 2017 | |
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| 520 | |a Tritrichomonas foetusis a flagellated protozoan that causes a sexually transmitted disease in cattle. Trichomonosis is characterized by early abortions, subfertility and a significant decrease in productivity. Vaccine preparations containing wholeT. foetuscan reduce the time of residence of the pathogen in the host cervix after experimental infection. Here,T. foetusvaccines prepared with different adjuvants were tested, in parallel with a commercial vaccine, for their efficacy to clear the infection. The median time for clearance of infection was 69days in non-immunized animals, 55days in animals treated with aluminum hydroxide, 41days with oil-in-water or saponin based vaccines or with a commercial vaccine and 27days in animals treated with saponin plus aluminum hydroxide. A slight increase in the risk ofT. foetusclearance from the genital tract was found with the saponin based vaccine (hazard ratio, 2.52; 95% confidence interval, 1.03-6.17) or the commercial vaccine (hazard ratio, 2.61; 95% confidence interval, 1.07-6.38). A significant increase in the risk ofT. foetusclearance was found with the combination of saponin plus aluminum hydroxide based vaccine (hazard ratio, 5.12; 95% confidence interval, 2.04-12.83). | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Cattle | |
| 650 | 4 | |a Antigens | |
| 650 | 4 | |a Mineral oils | |
| 650 | 4 | |a Aluminum | |
| 650 | 4 | |a Annual reports | |
| 650 | 4 | |a Vaccines | |
| 650 | 4 | |a Aqueous solutions | |
| 650 | 4 | |a Immunoglobulins | |
| 650 | 4 | |a Infections | |
| 700 | 1 | |a Fort, Marcelo C |4 oth | |
| 700 | 1 | |a Cano, Dora |4 oth | |
| 700 | 1 | |a Bonetti, Carina M |4 oth | |
| 700 | 1 | |a Giménez, Hugo D |4 oth | |
| 700 | 1 | |a Vázquez, Pablo M |4 oth | |
| 700 | 1 | |a Bacigalupe, Diana |4 oth | |
| 700 | 1 | |a Breccia, Javier D |4 oth | |
| 700 | 1 | |a Campero, Carlos M |4 oth | |
| 700 | 1 | |a Oyhenart, Jorge A |4 oth | |
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