Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms
Modeling the complete actin.myosin ATPase cycle has always been limited by the lack of experimental data concerning key steps of the cycle, because these steps can only be defined at very low ionic strength. Here, using human β-cardiac myosin-S1, we combine published data from transient and steady-state kinetics to model a minimal eight-state ATPase cycle. The model illustrates the occupancy of each intermediate around the cycle and how the occupancy is altered by changes in actin concentration for [actin] = 1-20..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:112 |
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| Enthalten in: |
Biophysical journal - 112(2017), 5, Seite 984 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Srbolujub M Mijailovich [VerfasserIn] |
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| Links: |
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| Themen: |
Adenosine triphosphatase |
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| Förderinstitution / Projekttitel: |
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OLC1992637954 |
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| 245 | 1 | 0 | |a Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms |
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| 520 | |a Modeling the complete actin.myosin ATPase cycle has always been limited by the lack of experimental data concerning key steps of the cycle, because these steps can only be defined at very low ionic strength. Here, using human β-cardiac myosin-S1, we combine published data from transient and steady-state kinetics to model a minimal eight-state ATPase cycle. The model illustrates the occupancy of each intermediate around the cycle and how the occupancy is altered by changes in actin concentration for [actin] = 1-20. | ||
| 650 | 4 | |a Muscular system | |
| 650 | 4 | |a Cardiovascular system | |
| 650 | 4 | |a Skeletal system | |
| 650 | 4 | |a Kinetics | |
| 650 | 4 | |a Adenosine triphosphatase | |
| 650 | 4 | |a Biophysics | |
| 700 | 0 | |a Djordje Nedic |4 oth | |
| 700 | 0 | |a Marina Svicevic |4 oth | |
| 700 | 0 | |a Boban Stojanovic |4 oth | |
| 700 | 0 | |a Jonathan Walklate |4 oth | |
| 700 | 0 | |a Zoltan Ujfalusi |4 oth | |
| 700 | 0 | |a Michael A Geeves |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Biophysical journal |d Bethesda, Md. : Biophysical Soc., 1960 |g 112(2017), 5, Seite 984 |w (DE-627)129544930 |w (DE-600)218078-9 |w (DE-576)01499500X |x 0006-3495 |7 nnns |
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