Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
Incidental cases of localized fibrin-associated Epstein-Barr virus (EBV)+ large B-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) in the WHO Classification. We describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of DLBCL-CI. Median age was 55.5 years with a M:F ratio of 3. In all 12 cases, the lymphoma was an incidental microscopic finding involving atrial myxomas (n=3), thrombi associated with endovascular grafts (n=3), chronic hematomas (n=2), and pseudocysts (n=4). All cases tested were nongerminal center B-cell origin, type III EBV latency, and were negative for MYC rearrangements and alternative lengthening of telomeres by FISH. Most showed high CD30, Ki67, and PD-L1, and low to moderate MYC and p53 expression. Among 11 patients with detailed follow-up, 6 were treated surgically, 3 with cardiac or vascular lesions had persistent/recurrent disease at intravascular sites, and 4 died of causes not directly attributable to lymphoma. Reports of previously published fibrin-associated cases showed similar features, whereas traditional DLBCL-CI cases with a mass lesion had significantly higher lymphoma-associated mortality. Fibrin-associated EBV+ large B-cell lymphoma is clinicopathologically distinct from DLBCL-CI, warranting separate classification. Most cases, particularly those associated with pseudocysts, behave indolently with the potential for cure by surgery alone and may represent a form of EBV+ lymphoproliferative disease rather than lymphoma. However, primary cardiac or vascular disease may have a higher risk of recurrence despite systemic chemotherapy..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
The American journal of surgical pathology - 41(2017), 3, Seite 299-312 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Boyer, Daniel F [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: |
|---|
| RVK: |
|---|
| doi: |
10.1097/PAS.0000000000000775 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1992483019 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1992483019 | ||
| 003 | DE-627 | ||
| 005 | 20230508062335.0 | ||
| 007 | tu | ||
| 008 | 170512s2017 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1097/PAS.0000000000000775 |2 doi | |
| 028 | 5 | 2 | |a PQ20170721 |
| 035 | |a (DE-627)OLC1992483019 | ||
| 035 | |a (DE-599)GBVOLC1992483019 | ||
| 035 | |a (PRQ)c1502-9362754beff833b18c7e01d9fc41c8045e0eced58656031d3cd47b385366888f0 | ||
| 035 | |a (KEY)0067726420170000041000300299fibrinassociatedebvpositivelargebcelllymphomaanind | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a XA 10000 |q AVZ |2 rvk | ||
| 084 | |a 44.47 |2 bkl | ||
| 084 | |a 44.65 |2 bkl | ||
| 100 | 1 | |a Boyer, Daniel F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Incidental cases of localized fibrin-associated Epstein-Barr virus (EBV)+ large B-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) in the WHO Classification. We describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of DLBCL-CI. Median age was 55.5 years with a M:F ratio of 3. In all 12 cases, the lymphoma was an incidental microscopic finding involving atrial myxomas (n=3), thrombi associated with endovascular grafts (n=3), chronic hematomas (n=2), and pseudocysts (n=4). All cases tested were nongerminal center B-cell origin, type III EBV latency, and were negative for MYC rearrangements and alternative lengthening of telomeres by FISH. Most showed high CD30, Ki67, and PD-L1, and low to moderate MYC and p53 expression. Among 11 patients with detailed follow-up, 6 were treated surgically, 3 with cardiac or vascular lesions had persistent/recurrent disease at intravascular sites, and 4 died of causes not directly attributable to lymphoma. Reports of previously published fibrin-associated cases showed similar features, whereas traditional DLBCL-CI cases with a mass lesion had significantly higher lymphoma-associated mortality. Fibrin-associated EBV+ large B-cell lymphoma is clinicopathologically distinct from DLBCL-CI, warranting separate classification. Most cases, particularly those associated with pseudocysts, behave indolently with the potential for cure by surgery alone and may represent a form of EBV+ lymphoproliferative disease rather than lymphoma. However, primary cardiac or vascular disease may have a higher risk of recurrence despite systemic chemotherapy. | ||
| 540 | |a Nutzungsrecht: Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 700 | 1 | |a McKelvie, Penelope A |4 oth | |
| 700 | 1 | |a de Leval, Laurence |4 oth | |
| 700 | 1 | |a Edlefsen, Kerstin L |4 oth | |
| 700 | 1 | |a Ko, Young-Hyeh |4 oth | |
| 700 | 1 | |a Aberman, Zachary A |4 oth | |
| 700 | 1 | |a Kovach, Alexandra E |4 oth | |
| 700 | 1 | |a Masih, Aneal |4 oth | |
| 700 | 1 | |a Nishino, Ha T |4 oth | |
| 700 | 1 | |a Weiss, Lawrence M |4 oth | |
| 700 | 1 | |a Meeker, Alan K |4 oth | |
| 700 | 1 | |a Nardi, Valentina |4 oth | |
| 700 | 1 | |a Palisoc, Maryknoll |4 oth | |
| 700 | 1 | |a Shao, Lina |4 oth | |
| 700 | 1 | |a Pittaluga, Stefania |4 oth | |
| 700 | 1 | |a Ferry, Judith A |4 oth | |
| 700 | 1 | |a Harris, Nancy Lee |4 oth | |
| 700 | 1 | |a Sohani, Aliyah R |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of surgical pathology |d [S.l.] : Wolters Kluwer Health, 1977 |g 41(2017), 3, Seite 299-312 |w (DE-627)13048492X |w (DE-600)752964-8 |w (DE-576)016071409 |x 0147-5185 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2017 |g number:3 |g pages:299-312 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1097/PAS.0000000000000775 |3 Volltext |
| 856 | 4 | 2 | |u http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000478-201703000-00002 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | r | v | |a XA 10000 |
| 936 | b | k | |a 44.47 |q AVZ |
| 936 | b | k | |a 44.65 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 41 |j 2017 |e 3 |h 299-312 | ||