Clinical epidemiology of acute hepatitis C in South America
There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at 13 hepatology units. All patients ≥16 years old with aHC diagnosis were included. Demographic, clinical and outcome information were registered in a standardized ad hoc questionnaire. Sixty-four patients were included. The majority were middle-aged (median age: 46 years) and female (65.6%); most of them were symptomatic at diagnosis (79.6%). HCV-1 was the most prevalent genotype (69.2%). Five patients had liver failure: three cases of severe acute hepatitis, one case of fulminant hepatitis and one case of acute-on-chronic liver failure. Nosocomial exposure was the most prevalent risk factor. Evolution was assessed in 46 patients. In the untreated cohort, spontaneous resolution occurred in 45.8% and was associated with higher values of AST/ALT and with the absence of intermittent HCV RNA viremia (P=0.01, 0.05, and 0.01, respectively). In the treated cohort, sustained virological response was associated with nosocomial transmission and early treatment initiation (P=0.04 each). The prevalence of nosocomial transmission in this South-American cohort of aHC stresses the importance of following universal precautions to prevent HCV infection. J. Med. Virol. 89:276-283, 2017. © 2016 Wiley Periodicals, Inc..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
|---|---|
| Enthalten in: |
Journal of medical virology - 89(2017), 2, Seite 276-283 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Dirchwolf, Melisa [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: | |
|---|---|
| Themen: |
Epidemiology |
| RVK: |
|---|
| doi: |
10.1002/jmv.24588 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1990261663 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1990261663 | ||
| 003 | DE-627 | ||
| 005 | 20230507231647.0 | ||
| 007 | tu | ||
| 008 | 170303s2017 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jmv.24588 |2 doi | |
| 028 | 5 | 2 | |a PQ20170301 |
| 035 | |a (DE-627)OLC1990261663 | ||
| 035 | |a (DE-599)GBVOLC1990261663 | ||
| 035 | |a (PRQ)c1918-1a97033f74871b406815263bd1a7d14cb0b691a0f62bb6bdf68b19664c527afa3 | ||
| 035 | |a (KEY)0015763520170000089000200276clinicalepidemiologyofacutehepatitiscinsouthameric | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 084 | |a XA 10000 |q AVZ |2 rvk | ||
| 084 | |a 44.00 |2 bkl | ||
| 100 | 1 | |a Dirchwolf, Melisa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical epidemiology of acute hepatitis C in South America |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at 13 hepatology units. All patients ≥16 years old with aHC diagnosis were included. Demographic, clinical and outcome information were registered in a standardized ad hoc questionnaire. Sixty-four patients were included. The majority were middle-aged (median age: 46 years) and female (65.6%); most of them were symptomatic at diagnosis (79.6%). HCV-1 was the most prevalent genotype (69.2%). Five patients had liver failure: three cases of severe acute hepatitis, one case of fulminant hepatitis and one case of acute-on-chronic liver failure. Nosocomial exposure was the most prevalent risk factor. Evolution was assessed in 46 patients. In the untreated cohort, spontaneous resolution occurred in 45.8% and was associated with higher values of AST/ALT and with the absence of intermittent HCV RNA viremia (P=0.01, 0.05, and 0.01, respectively). In the treated cohort, sustained virological response was associated with nosocomial transmission and early treatment initiation (P=0.04 each). The prevalence of nosocomial transmission in this South-American cohort of aHC stresses the importance of following universal precautions to prevent HCV infection. J. Med. Virol. 89:276-283, 2017. © 2016 Wiley Periodicals, Inc. | ||
| 540 | |a Nutzungsrecht: © 2016 Wiley Periodicals, Inc. | ||
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a nosocomial transmission | |
| 650 | 4 | |a hepatitis C virus | |
| 650 | 4 | |a Latin America | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Hepatitis | |
| 650 | 4 | |a Health risk assessment | |
| 700 | 1 | |a Marciano, Sebastián |4 oth | |
| 700 | 1 | |a Mauro, Ezequiel |4 oth | |
| 700 | 1 | |a Ruf, Andrés Eduardo |4 oth | |
| 700 | 1 | |a Rezzonico, Lucrecia |4 oth | |
| 700 | 1 | |a Anders, Margarita |4 oth | |
| 700 | 1 | |a Chiodi, Daniela |4 oth | |
| 700 | 1 | |a Petta, Néstor Gill |4 oth | |
| 700 | 1 | |a Borzi, Silvia |4 oth | |
| 700 | 1 | |a Tanno, Federico |4 oth | |
| 700 | 1 | |a Ridruejo, Ezequiel |4 oth | |
| 700 | 1 | |a Barreyro, Fernando |4 oth | |
| 700 | 1 | |a Shulman, Carolina |4 oth | |
| 700 | 1 | |a Plaza, Pablo |4 oth | |
| 700 | 1 | |a Carbonetti, Rodolfo |4 oth | |
| 700 | 1 | |a Tadey, Luciana |4 oth | |
| 700 | 1 | |a Schroder, Teresa |4 oth | |
| 700 | 1 | |a Fainboim, Hugo |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of medical virology |d Hoboken, NJ : Wiley-Liss, 1977 |g 89(2017), 2, Seite 276-283 |w (DE-627)130482439 |w (DE-600)752392-0 |w (DE-576)016070275 |x 0146-6615 |7 nnns |
| 773 | 1 | 8 | |g volume:89 |g year:2017 |g number:2 |g pages:276-283 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1002/jmv.24588 |3 Volltext |
| 856 | 4 | 2 | |u http://onlinelibrary.wiley.com/doi/10.1002/jmv.24588/abstract |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1845028044 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_4012 | ||
| 936 | r | v | |a XA 10000 |
| 936 | b | k | |a 44.00 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 89 |j 2017 |e 2 |h 276-283 | ||