Croton gratissimus Leaf Essential Oil Composition, Antibacterial, Antiplatelet Aggregation, and Cytotoxic Activities
Essential oil hydrodistilled from the leaves of Croton gratissimus was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) to identify the constituents by comparison of their mass spectra (MS) data and linear retention indices (LRI) with literature. Forty constituents corresponding to 96.7% of the total oil content were identified from the oil sample. The major compounds were sabinene (14.6%), α-phellandrene (12.3%), β-phellandrene (10.7%), α-pinene (6.05%), and germacrene D (5.9%). The essential oil exhibited stronger antibacterial activity with minimum inhibitory concentration (MIC) of 0.6 mg.mL -1 (Staphylococcus aureus), 0.2 mg.mL -1 (S. faecalis), and 1.3 mg.mL -1 (Escherichia coli and Bacillus cereus). In the antiplatelet aggregation inhibitory activity, the oil displayed action against the induced platelet aggregation in the order collagen (IC 50 < 1) > thrombin (IC 50 1.18) > Adenosine diphosphate (IC 50 2.32) > epinephrine (IC 50 3.65). The lethal concentration (LC 50 ) of the oil at 8.52 mg.mL -1 was toxic to Artemia salina..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Journal of herbs, spices & medicinal plants - 23(2017), 1, Seite 77-87 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lawal, Oladipupo A [VerfasserIn] |
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| Links: |
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| BKL: | |
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| Themen: |
Anti-platelet aggregation |
| doi: |
10.1080/10496475.2016.1270245 |
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OLC1989337260 |
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| 520 | |a Essential oil hydrodistilled from the leaves of Croton gratissimus was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) to identify the constituents by comparison of their mass spectra (MS) data and linear retention indices (LRI) with literature. Forty constituents corresponding to 96.7% of the total oil content were identified from the oil sample. The major compounds were sabinene (14.6%), α-phellandrene (12.3%), β-phellandrene (10.7%), α-pinene (6.05%), and germacrene D (5.9%). The essential oil exhibited stronger antibacterial activity with minimum inhibitory concentration (MIC) of 0.6 mg.mL -1 (Staphylococcus aureus), 0.2 mg.mL -1 (S. faecalis), and 1.3 mg.mL -1 (Escherichia coli and Bacillus cereus). In the antiplatelet aggregation inhibitory activity, the oil displayed action against the induced platelet aggregation in the order collagen (IC 50 < 1) > thrombin (IC 50 1.18) > Adenosine diphosphate (IC 50 2.32) > epinephrine (IC 50 3.65). The lethal concentration (LC 50 ) of the oil at 8.52 mg.mL -1 was toxic to Artemia salina. | ||
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