Randomized clinical trial of extended versus single-dose perioperative antibiotic prophylaxis for acute calculous cholecystitis
Many patients who have surgery for acute cholecystitis receive postoperative antibiotic prophylaxis, with the intent to reduce infectious complications. There is, however, no evidence that extending antibiotics beyond a single perioperative dose is advantageous. This study aimed to determine the effect of extended antibiotic prophylaxis on infectious complications in patients with mild acute cholecystitis undergoing cholecystectomy. In the intention-to-treat analysis, three of 77 patients (4 per cent) in the extended antibiotic group and three of 73 (4 per cent) in the standard prophylaxis group developed postoperative infectious complications (absolute difference 0ae2 (95 per cent c.i. -8ae2 to 8ae9) per cent). Based on a margin of 5 per cent, non-inferiority of standard prophylaxis compared with extended prophylaxis was not proven. Median length of hospital stay was 3 days in the extended antibiotic group and 1 day in the standard prophylaxis group. Standard single-dose antibiotic prophylaxis did not lead to an increase in postoperative infectious complications in patients with mild acute cholecystitis undergoing cholecystectomy. Registration number: NTR3089 (www.trialregister.nl)..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
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| Enthalten in: |
The British journal of surgery - 104(2017), 2, Seite e151 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boerma, D [VerfasserIn] |
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| Links: |
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| Themen: |
Antibiotics |
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| doi: |
10.1002/bjs.10406 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Many patients who have surgery for acute cholecystitis receive postoperative antibiotic prophylaxis, with the intent to reduce infectious complications. There is, however, no evidence that extending antibiotics beyond a single perioperative dose is advantageous. This study aimed to determine the effect of extended antibiotic prophylaxis on infectious complications in patients with mild acute cholecystitis undergoing cholecystectomy. In the intention-to-treat analysis, three of 77 patients (4 per cent) in the extended antibiotic group and three of 73 (4 per cent) in the standard prophylaxis group developed postoperative infectious complications (absolute difference 0ae2 (95 per cent c.i. -8ae2 to 8ae9) per cent). Based on a margin of 5 per cent, non-inferiority of standard prophylaxis compared with extended prophylaxis was not proven. Median length of hospital stay was 3 days in the extended antibiotic group and 1 day in the standard prophylaxis group. Standard single-dose antibiotic prophylaxis did not lead to an increase in postoperative infectious complications in patients with mild acute cholecystitis undergoing cholecystectomy. Registration number: NTR3089 (www.trialregister.nl). | ||
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| 650 | 4 | |a Medical care | |
| 650 | 4 | |a Cholecystitis | |
| 650 | 4 | |a Dosage and administration | |
| 650 | 4 | |a Antibiotics | |
| 650 | 4 | |a Clinical trials | |
| 650 | 4 | |a Quality management | |
| 650 | 4 | |a Hospitals | |
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| 700 | 1 | |a Gouma, D. J |4 oth | |
| 700 | 1 | |a Bos, W. J. W |4 oth | |
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| 700 | 1 | |a Kornmann, V. N. N |4 oth | |
| 700 | 1 | |a Knibbe, C. A. J |4 oth | |
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| 700 | 1 | |a van Geloven, A. A. W |4 oth | |
| 700 | 1 | |a van Duijvendijk, P |4 oth | |
| 700 | 1 | |a Kortram, K |4 oth | |
| 700 | 1 | |a van Ramshorst, B |4 oth | |
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