Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs
A series of aryltetralin lignans 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized as cytotoxic isodeoxypodophyllotoxin analogs. The title compounds 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized from the reaction of (+)-(R)-4-[benzo(d)(1,3)dioxol-5-ylmethyl]-dihydrofuran-2-(3H)-one with different arylaldehydes to afford benzyl alcohol analogs and subsequent cyclization with trifluoroacetic acid in dichromethane. The preliminary screening of the compounds against viability of blood cancer human cell line K562 revealed that compounds 7d, 7e, and 7f had higher inhibitory activity at 10µg/mL concentration compared with etoposide as reference drug..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
|---|---|
| Enthalten in: |
Journal of heterocyclic chemistry - 54(2017), 1, Seite 539-545 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Alizadeh, Babak Heidary [VerfasserIn] |
|---|
| Links: |
|---|
| RVK: |
|---|
| doi: |
10.1002/jhet.2618 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1987525175 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1987525175 | ||
| 003 | DE-627 | ||
| 005 | 20230511153601.0 | ||
| 007 | tu | ||
| 008 | 170207s2017 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jhet.2618 |2 doi | |
| 028 | 5 | 2 | |a PQ20170206 |
| 035 | |a (DE-627)OLC1987525175 | ||
| 035 | |a (DE-599)GBVOLC1987525175 | ||
| 035 | |a (PRQ)c865-cd41026e248facc0082e3908670dd862be43117f13db3c1092a3339f7a5d0e7e3 | ||
| 035 | |a (KEY)0040749620170000054000100539synthesisofcytotoxicisodeoxypodophyllotoxinanalogs | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 540 |q DE-600 |
| 084 | |a VA 5200 |q AVZ |2 rvk | ||
| 100 | 1 | |a Alizadeh, Babak Heidary |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a A series of aryltetralin lignans 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized as cytotoxic isodeoxypodophyllotoxin analogs. The title compounds 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized from the reaction of (+)-(R)-4-[benzo(d)(1,3)dioxol-5-ylmethyl]-dihydrofuran-2-(3H)-one with different arylaldehydes to afford benzyl alcohol analogs and subsequent cyclization with trifluoroacetic acid in dichromethane. The preliminary screening of the compounds against viability of blood cancer human cell line K562 revealed that compounds 7d, 7e, and 7f had higher inhibitory activity at 10µg/mL concentration compared with etoposide as reference drug. | ||
| 700 | 1 | |a Emami, Saeed |4 oth | |
| 700 | 1 | |a Dehghan, Gholamreza |4 oth | |
| 700 | 1 | |a Foroumadi, Alireza |4 oth | |
| 700 | 1 | |a Shafiee, Abbas |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of heterocyclic chemistry |d Hoboken, NJ : Wiley, 1964 |g 54(2017), 1, Seite 539-545 |w (DE-627)12954518X |w (DE-600)218131-9 |w (DE-576)01499531X |x 0022-152X |7 nnns |
| 773 | 1 | 8 | |g volume:54 |g year:2017 |g number:1 |g pages:539-545 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1002/jhet.2618 |3 Volltext |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1860645863 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_4012 | ||
| 936 | r | v | |a VA 5200 |
| 951 | |a AR | ||
| 952 | |d 54 |j 2017 |e 1 |h 539-545 | ||