Evaluation of ANA-related Serologic Autoantibodies in Polycystic Ovary Syndrome
Objectives: To evaluate the serum levels of common autoimmune parameters in women with polycystic ovary syndrome (PCOS) and compare with the control group. Design: prospective case-control study. Setting: Academic research institution. Patients: 102 women with PCOS and 100 healthy controls. Interventions: Questionnaire, physical examination, sonography, blood sampling. Main outcome measure(s): Serum levels of Anti Ds-DNA, Anti SS-A, Anti SS-B, Anti Sm, Anti RNP/sm, Anti Scl70and Anti jo-1 were evaluated in PCOS patients and control group by enzyme immunoassays. Results: No significant differences were detected between cases and controls in the level of antibodies and in the correlation between Biochemical markers (FSH, LH, TSH, Prolactin, Testosterone and DHEAS). Only higher scores of hirsutism showed a statistically significant correlation with Anti sm Ab. Conclusion: Our study showed that serologic markers of autoimmunity (Anti ds-DNA & ANAs) are not elevated in PCOS patients. However, severity of hirsutism was found to have a statistically significant correlation with anti sm Ab, so maybe with repeat to these tests in future trials, the exact relationship will be revealed..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2014 |
|---|---|
| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Immunology, endocrine & metabolic agents in medicinal chemistry - 14(2014), 1, Seite 21-25 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hamedi, Bahareh [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
OLC1986720713 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC1986720713 | ||
| 003 | DE-627 | ||
| 005 | 20230518124702.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170131s2014 xx |||||o 00| ||eng c | ||
| 028 | 5 | 2 | |a fidpha_zeitschriften_20170130.pp |
| 035 | |a (DE-627)OLC1986720713 | ||
| 035 | |a (DE-599)GBVOLC1986720713 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |
| 084 | |a PHARM |2 fid | ||
| 084 | |a 44.40 |2 bkl | ||
| 100 | 1 | |a Hamedi, Bahareh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of ANA-related Serologic Autoantibodies in Polycystic Ovary Syndrome |
| 264 | 1 | |c 2014 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objectives: To evaluate the serum levels of common autoimmune parameters in women with polycystic ovary syndrome (PCOS) and compare with the control group. Design: prospective case-control study. Setting: Academic research institution. Patients: 102 women with PCOS and 100 healthy controls. Interventions: Questionnaire, physical examination, sonography, blood sampling. Main outcome measure(s): Serum levels of Anti Ds-DNA, Anti SS-A, Anti SS-B, Anti Sm, Anti RNP/sm, Anti Scl70and Anti jo-1 were evaluated in PCOS patients and control group by enzyme immunoassays. Results: No significant differences were detected between cases and controls in the level of antibodies and in the correlation between Biochemical markers (FSH, LH, TSH, Prolactin, Testosterone and DHEAS). Only higher scores of hirsutism showed a statistically significant correlation with Anti sm Ab. Conclusion: Our study showed that serologic markers of autoimmunity (Anti ds-DNA & ANAs) are not elevated in PCOS patients. However, severity of hirsutism was found to have a statistically significant correlation with anti sm Ab, so maybe with repeat to these tests in future trials, the exact relationship will be revealed. | ||
| 700 | 1 | |a Sarvestani, Eskandar K. |e verfasserin |4 aut | |
| 700 | 1 | |a Khalili, Azadeh |e verfasserin |4 aut | |
| 700 | 1 | |a Fard, Mahboobeh B. |e verfasserin |4 aut | |
| 700 | 1 | |a Alborzi, Saeed |e verfasserin |4 aut | |
| 700 | 1 | |a Davoodi, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Nazarinia, Mohammad A. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunology, endocrine & metabolic agents in medicinal chemistry |d San Francisco, Calif. : Bentham Science Publ., 2006 |g 14(2014), 1, Seite 21-25 |w (DE-627)507526643 |w (DE-600)2221719-8 |w (DE-576)435514261 |x 1871-5222 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2014 |g number:1 |g pages:21-25 |
| 856 | 4 | 0 | |u http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1871-5222&volume=14&issue=1&spage=21 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a FID-PHARM | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-PHA | ||
| 912 | |a GBV_ILN_20 | ||
| 936 | b | k | |a 44.40 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 14 |j 2014 |e 1 |h 21-25 | ||