A Simple Extraction Procedure for HPLC Analysis of Fluoxetine in Rat Plasma Samples
In present study, a simple liquid-liquid extraction-high performance liquid chromatography-fluorescence method was developed for the determination of fluoxetine (FLU) in rat plasma samples. A MZ Analytical Column C18 (250 mm x 4.6 mm, 5µm i.d.) was used for the separation of FLU. The total analysis time was less than 7 minutes. The rat plasma samples were simply treated with acetonitrile and analyzed using developed method. The recovery of the FLU from rat plasma samples is 92.70% ± 0.48. FLU in spiked rat plasma samples provided linear data over a range of 0.2 - 2.00 µg mL-1. The method was validated according to the FDA guidelines and can be proposed for quantification of FLU in rat plasma..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Current pharmaceutical analysis - 13(2017), 1, Seite 80-84 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Recber, Tuba [VerfasserIn] |
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| PPN (Katalog-ID): |
OLC1986715981 |
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| 520 | |a In present study, a simple liquid-liquid extraction-high performance liquid chromatography-fluorescence method was developed for the determination of fluoxetine (FLU) in rat plasma samples. A MZ Analytical Column C18 (250 mm x 4.6 mm, 5µm i.d.) was used for the separation of FLU. The total analysis time was less than 7 minutes. The rat plasma samples were simply treated with acetonitrile and analyzed using developed method. The recovery of the FLU from rat plasma samples is 92.70% ± 0.48. FLU in spiked rat plasma samples provided linear data over a range of 0.2 - 2.00 µg mL-1. The method was validated according to the FDA guidelines and can be proposed for quantification of FLU in rat plasma. | ||
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