In-Vitro and In-Vivo Pharmacological Activities with Phytochemical Evaluation of Methanolic Extract of Microcos paniculata Stem Barks
Background and Objectives: Microcos paniculata is widely distributed throughout the Bangladesh which belongs to the family Tiliaceae. The present study was considered to determine anti-diarrheal, analgesic, membrane stabilizing and thrombolytic activities with evaluation of phytochemical nature of methanolic extract of M. paniculata steam bark. Methods: Methanolic extract of this plant part was prepared at room temperature and the concentrated methanolic extracts used for the phytochemical screenings by using appropriate and proper procedure for the investigation of phytoconstituents. The extract was then used for investigation of in-vitro thrombolytic and membrane stabilizing activity. The in-vivo antidiarrheal and analgesic activities were done according to the method of castor oil and acetic acid induce writhing respectively. Results: Phytochemical study reveal the presence of flavonoids, diterpenes, alkaloids, saponin, tannin and phenols. During the estimation of anti-diarrheal activity plant extract showed most significant inhibition of 63.30% and 56.70% diarrhea at 400 mg/kg and 200 mg/kg, respectively. Analgesic test showed pain inhibition of 41.36% and 32.0% at 500 mg/kg and 250 mg/kg, respectively in contrast to standard drug (Ibuprofen) showed 46.64% inhibition of pain. The membrane stabilizing study showed that the inhibition of hemolysis increases respectively when the dose increased. Similar result was found in thrombolytic activity which means that when the dose increased, the thrombolytic activity of the plant extract increased. Conclusion: By considering this result, it can be concluded that M. paniculata may lead to find novel drugs for cardiovascular and diarrheal patient and also bring hope for patients suffering with diverse pain..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Current drug therapy - 11(2016), 2, Seite 142-149 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Md. Al-Amin Sarker [VerfasserIn] |
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| Links: |
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| doi: |
10.2174/1574885511666160520154529 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC1986443175 |
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| 520 | |a Background and Objectives: Microcos paniculata is widely distributed throughout the Bangladesh which belongs to the family Tiliaceae. The present study was considered to determine anti-diarrheal, analgesic, membrane stabilizing and thrombolytic activities with evaluation of phytochemical nature of methanolic extract of M. paniculata steam bark. Methods: Methanolic extract of this plant part was prepared at room temperature and the concentrated methanolic extracts used for the phytochemical screenings by using appropriate and proper procedure for the investigation of phytoconstituents. The extract was then used for investigation of in-vitro thrombolytic and membrane stabilizing activity. The in-vivo antidiarrheal and analgesic activities were done according to the method of castor oil and acetic acid induce writhing respectively. Results: Phytochemical study reveal the presence of flavonoids, diterpenes, alkaloids, saponin, tannin and phenols. During the estimation of anti-diarrheal activity plant extract showed most significant inhibition of 63.30% and 56.70% diarrhea at 400 mg/kg and 200 mg/kg, respectively. Analgesic test showed pain inhibition of 41.36% and 32.0% at 500 mg/kg and 250 mg/kg, respectively in contrast to standard drug (Ibuprofen) showed 46.64% inhibition of pain. The membrane stabilizing study showed that the inhibition of hemolysis increases respectively when the dose increased. Similar result was found in thrombolytic activity which means that when the dose increased, the thrombolytic activity of the plant extract increased. Conclusion: By considering this result, it can be concluded that M. paniculata may lead to find novel drugs for cardiovascular and diarrheal patient and also bring hope for patients suffering with diverse pain. | ||
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