Highly Luminescent Heterostructured Copper‐Doped Zinc Sulfide Nanocrystals for Application in Cancer Cell Labeling
The structural characteristics of the seed‐mediated synthesis of heterostructured CuS–ZnS nanocrystals (NCs) and Cu‐doped ZnS (ZnS:Cu) NCs synthesized by two different protocols are compared and analyzed. At high Cu dopant concentrations, segregated subclusters of ZnS and CuS are observed. The photoluminescence quantum yield of ZnS:Cu NCs is about 50–80 %; a value much higher than that of ZnS NCs (6 %). Finally, these NCs are coated with a thin silica shell by using (3‐mercaptopropyl)triethoxysilane in a reverse microemulsion to make them water soluble. Cytotoxicity experiments show that these silica‐coated NCs have greatly reduced toxicity on both cancerous HeLa and noncancerous Chinese hamster ovary cells. The labeling of cancerous HeLa cells is also demonstrated. Copper influence : Doped nanocrystals behave like heterostructured CuS−ZnS nanocrystals and form segregated subclusters or short rods at high Cu dopant concentrations, with an intense blue emission and a high quantum yield. Silica‐coated nanocrystals exhibit low toxicity and are useful for the labeling of HeLa cells (see figure)..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
ChemPhysChem - 17(2016), 16, Seite 2489-2495 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ang, Huixiang [VerfasserIn] |
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| Links: |
Volltext |
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| BKL: | |
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| Themen: |
Cancer |
| doi: |
10.1002/cphc.201600415 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The structural characteristics of the seed‐mediated synthesis of heterostructured CuS–ZnS nanocrystals (NCs) and Cu‐doped ZnS (ZnS:Cu) NCs synthesized by two different protocols are compared and analyzed. At high Cu dopant concentrations, segregated subclusters of ZnS and CuS are observed. The photoluminescence quantum yield of ZnS:Cu NCs is about 50–80 %; a value much higher than that of ZnS NCs (6 %). Finally, these NCs are coated with a thin silica shell by using (3‐mercaptopropyl)triethoxysilane in a reverse microemulsion to make them water soluble. Cytotoxicity experiments show that these silica‐coated NCs have greatly reduced toxicity on both cancerous HeLa and noncancerous Chinese hamster ovary cells. The labeling of cancerous HeLa cells is also demonstrated. Copper influence : Doped nanocrystals behave like heterostructured CuS−ZnS nanocrystals and form segregated subclusters or short rods at high Cu dopant concentrations, with an intense blue emission and a high quantum yield. Silica‐coated nanocrystals exhibit low toxicity and are useful for the labeling of HeLa cells (see figure). | ||
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